Feasibility and prognostic value of vasodilator stress perfusion Cardiac Magnetic Resonance in elderly patients > 75 years without known CAD - 06/01/20
Résumé |
Background |
The World's ageing population with a life expectancy that is steadily increasing raises the question of the benefit of screening for coronary artery disease (CAD) in very old patients.
Purpose |
To assess the prognostic value of vasodilator stress perfusion Cardiac Magnetic Resonance (CMR) in elderly patients aged>75years without known CAD.
Materiel |
Consecutive elderly patients>75years without known CAD referred for vasodilator stress perfusion CMR were followed for major adverse cardiovascular events(MACE) defined as cardiac death, non-fatal myocardial infarction or stroke. Univariable and multivariable Cox regressions for MACE were performed to assess the prognostic value of inducible ischemia and late gadolinium enhancement (LGE).
Results |
Of 747 elderly high risk patients with CMR (82±4years, 48% men), 659 (88%) completed the follow-up (median follow-up 5.7±2.5years). Stress CMR was well tolerated without occurrence of severe disabling adverse event. Patients without inducible ischemia or LGE experienced a substantially lower annual rate of MACE (5.5% vs. 9.9% for those with ischemia and vs. 6.9% for those with ischemia and/or LGE). In multivariable analysis, the absence of inducible ischemia was an independent predictor of a lower incidence of MACE (HR 0.46; 95%CI: 0.34 to 0.62; P<0.001; Fig. 1A) and all-cause mortality (HR 0.67; 95%CI: 0.45 to 0.97; P=0.037). When patients with early coronary revascularization (within 30days) were censored on the day of revascularization, both presence of inducible ischemia and ischemia extent per segment maintained a strong association with MACE. Moreover, the absence of inducible ischemia was a predictor of a lower incidence of MACE less significant in men than in women (P<0.01; Fig. 1B).
Conclusion |
Stress CMR is safe and has discriminative prognostic value in very elderly patients, with a very low negative event rate in patients without ischemia or infarction.
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Vol 12 - N° 1
P. 61 - janvier 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.