Echocardiographic assessment of diastolic function in asymptomatic systemic lupus erythematosus (SLE) patients - 06/01/20
Résumé |
Introduction |
Cardiac disease is common among patients with systemic lupus erythematosus (SLE) even when clinically asymptomatic but diastolic dysfunction is infrequently reported.
Purpose |
The aim of our study was to assess diastolic left ventricular dysfunction at a subclinical stage and to compare the obtained results with a control population.
Methods |
We conducted a prospective study over a period of seven years from 2008 to 2015 in the echocardiography laboratory of the adult cardiology department of La Rabta Hospital. Thirty consecutive SLE patients without evidence of cardiac disease were enrolled (group A), and were compared with 30 age-matched healthy control subjects (group B).
Results |
The average age of our patients was 41±8 years old. There were 25 women (83.3%) and 5 men (16.66%). All had normal LV systolic function; There were no statistically significant differences between SLE patients and controls in such parameters as; peak early diastolic filling velocity (E) LV between the 2 groups A and B (90±12cm/s vs. 85±10cm/s), the peak late diastolic velocity A, (66±9cm/s vs. 60±9cm/s), the Ratio of Peak Early to Late Diastolic Filling Velocity of Transmitral Flow E/A (1.32±0.3 vs. 1.4±0.4) and the E wave deceleration (181±8ms vs. 200±22ms). Early diastolic mitral annular velocity (Ea) was decreased in lupus patients compared to controls (7.0±0.5cm/s vs. 11.5±2.4cm/s, P<0.01).The difference in the duration between the pulmonary venous atrial reversal and the mitral inflow A wave Ar-Am was longer in group B, and the E/Ea ratio was significantly higher in lupus patients than in healthy subjects (13.1±1.1 vs. 7.6±1.2, P<0.01) (Table 1).
Conclusion |
Echocardiography seems to be an excellent non-invasive tool for early detection of subclinical impaired diastolic cardiac function. So we suggest that patients with SLE, should better undergo an echocardiographic evaluation, and be followed periodically.
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Vol 12 - N° 1
P. 71 - janvier 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.