Advances in research into the mechanisms of Chinese Materia Medica against acute lung injury - 08/01/20
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Graphical abstract |
Highlights |
• | It lays the foundation for the future development of new CMM-based anti-ALI and other drug formulations. |
• | It provides fundamental theoretical support for the discovery and use of CMM resources through the comprehensive analysis of various anti-ALI CMM report databases. |
• | It augments the anti-ALI theory of CMM and establishes the clinical significance and the prospects for the development of CMM-based treatments for ALI and other disorders. |
• | It compiles and presents empirical evidence for comparative efficacy and safety of Chinese Materia Medica in the treatment of acute lung injury. |
Abstract |
Acute lung injury (ALI) is a common and serious disease. Numerous treatment options are available but they do not improve quality of life or reduce mortality for ALI patients. Here, we review the treatments for ALI to provide basic data for ALI drug therapy research and development. Chinese Materia Medica (CMM) has long been the traditional clinical approach in China for the treatment of ALI and it has proven efficacy. The continued study of CMM has disclosed new potential therapeutic ingredients for ALI. However, few reviews summarize the currently available CMM-based anti-ALI drugs. Therefore, the systematic analysis of research progress in anti-ALI CMM is of great academic and clinical value. The aim of the present review is to describe CMM-based research progress in ALI treatment. Data were compiled by electronic retrieval (CNKI, SciFinder, PubMeds, Google Scholar, Web of Science) and from articles, patents and ethnopharmacological literature in university libraries were systematically studied. This review introduces progress in research on the etiology and mechanisms of ALI, the anti-ALI theory and modes of action in traditional Chinese medicine (TCM), anti-ALI active constituents of CMM, research progress in experimental methods of CMM anti-ALI, the anti-ALI molecular mechanisms of CMM, the anti-ALI efficacy of CMM formulae, and the potential toxicity of CMM and the antidotes for it. Scholars have investigated the anti-ALI molecular mechanism of CMM from various direction and have made substantial progress. This research explored the above aspects, enriched the anti-ALI theory of CMM and established the clinical significance and developmental prospects of ALI treatment by CMM. Because of the high frequency of drugs such as glucocorticoids or antibiotics, Western medicine lacks the advantages of CMM in terms of overall anti-ALI efficacy. In the future, the development of CMM-based anti-ALI therapies will become a major trend in the field of ALI drug development. Successful clinical safety and efficacy validations will promote and encourage the use of CMM. It provides fundamental theoretical support for the discovery and use of CMM resources through the comprehensive analysis of various anti-ALI CMM report databases.
Le texte complet de cet article est disponible en PDF.Abbreviations : ALI, AMPK, APAF1, Apo-3L, ARDS, AT Ι, ATP, BALF, CLP, CMM, COX-2, DAD, DISC, ENaC, ERK, Fas-L, GSH-Px, HIF-1α, HMGB1, HO-1, IL-1, IL-6, iNOS, IκB, JNK, LPS, LT-α, MAPK, MDA, NF-κB, NO, NSAIDs, PMN, PPAR, ROS, SOD, TCM, TLR, TNF-α, NLRP3, PI3K, mTOR
Keywords : Review, Chinese Materia Medica, Acute lung injury, Anti-ALI effect, Anti-ALI disease ingredient
Plan
Vol 122
Article 109706- février 2020 Retour au numéro
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