PSMB8-AS1 activated by ELK1 promotes cell proliferation in glioma via regulating miR-574-5p/RAB10 - 08/01/20
, Fulin Xu a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | PSMB8-AS1 expression is upregulated in glioma tissues and cells. |
• | PSMB8-AS1 binds with miR-574-5p in glioma. |
• | RAB10 is targeted by miR-574-5p in glioma. |
• | PSMB8-AS1 promotes glioma proliferation via regulating miR-574-5p/RAB10. |
• | PSMB8-AS1 is activated by ELK1 in glioma. |
Abstract |
Long noncoding RNAs (lncRNAs) get great involvements in the development of countless cancers. Nonetheless, the deep molecular mechanism by which lncRNA regulates the formation of glioma is unclear. In our study, the expression of PSMB8-AS1 was dramatically upregulated in glioma tissues and cells, further, PSMB8-AS1 silencing restrained cell proliferation in glioma, and the results of PSMB8-AS1 overexpression were opposite. Moreover, PSMB8-AS1 could bind with miR-574-5p, which was low expressed in glioma cells. In addition, RAB10 acted the target gene of miR-574-5p, and PSMB8-AS1 could regulate RAB10 via modulating miR-574-5p. Besides, miR-574-5p inhibitor/mimics remedied the repressive/simulative role of PSMB8-AS1 depletion/overexpression, and RAB10 downregulation/upregulation reversed the encouraging/blocked function caused by miR-574-5p inhibitor/mimics in PSMB8-AS1 depletion/overexpression transfected glioma cells. Additionally, ELK1, a transcription factor, could active PSMB8-AS1 expression. To be concluded, PSMB8-AS1 activated by ELK1 promotes cell proliferation in glioma via regulating miR-574-5p/RAB10, which may be contributory to find new targets to treat glioma.
Le texte complet de cet article est disponible en PDF.Keywords : Glioma, PSMB8-AS1, miR-574-5p, RAB10, ELK1
Plan
Vol 122
Article 109658- février 2020 Retour au numéro
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