Bacterial particles retard tumor growth as a novel vascular disrupting agent - 08/01/20
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Highlights |
• | BactPs retarded tumor growth by inducing extensive tumor hemorrhage and necrosis. |
• | BactPs disrupted tumor vasculature extensively in solid tumor interior selectively. |
• | BactPs induced significant alternations of cytokines in mice sera and tumor tissues. |
• | A combination of six cytokines exerted the function of tumor vascular disruption. |
Abstract |
Due to hypoxia and poor circulation in the tumor interior, malignant cells in solid tumors are resistant to traditional therapies. In the present study, we reported that bacterial particles (BactPs) functioned effectively in retarding tumor growth as a novel vascular disrupting agent. The BactPs were inactivated intact bacteria. Intravenous administration of BactPs extensively disrupted vessels in the tumor interior, but not in normal organs, and resulted in tumor hemorrhage and necrosis in six hours. We revealed that the extensive disruption of tumor vasculature was due to drastic changes in the inflammatory factors in mice sera and the tumor microenvironments, indicating the critical role of the host immune response to the BactPs. Furthermore, we showed that a combination of six inflammatory cytokines was capable of inducing tumor hemorrhage and necrosis, similar to the effects of the BactPs. Together, these results suggest that BactPs are a novel kind of tumor vascular disruptor with a promising potential for solid tumor treatment.
Le texte complet de cet article est disponible en PDF.Keywords : Bacterial particle, Vascular disrupting agent, Tumor microenvironments, Inflammatory cytokines
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Vol 122
Article 109757- février 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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