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The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed.
To validate PIQ short forms in adults with AD.
Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermatology practice setting.
PIQ items had good content validity. PIQ item bank T-scores strongly correlated with each other, moderately correlated with numeric and verbal rating scales for worst or average itch and with itch frequency, moderately to strongly correlated with patient-oriented eczema measure, and weakly to moderately correlated with the Eczema Area and Severity Index and Objective-Scoring AD (Spearman correlations, P < .0001). There were significant and stepwise increases of T-scores for all item banks with increasing patient-reported global severity (Wilcoxon rank sum test, P < .0001). However, there was limited ability to discriminate between the lowest or highest 2 levels of AD or itch severity. Item banks showed good internal consistency (Cronbach α, 0.91-0.95). No differential item functioning was identified by age, sex, race/ethnicity, or educational level. There were floor effects for total scores, particularly in almost clear/mild AD or itch.
PIQ item bank short forms showed good content and construct validity and are feasible for potential use in clinical trials and practice.Le texte complet de cet article est disponible en PDF.
Key Words : atopic dermatitis, burden, eczema, itch, patient-reported outcomes, quality of life, severity, pruritus
Abbreviations used : 5D-Itch, AD, ClinRO, DIF, DLQI, EASI, NRS, oSCORAD, PIQ, POEM, PRO, QOL, SCORAD, SD, SF, VRS
| Funding sources: Supported by the Agency for Healthcare Research and Quality grant K12 HS023011, the Dermatology Foundation, and a research grant from Galderma.
| Conflicts of interest: None disclosed.
| IRB approval status: Reviewed and approved by the IRBs of Northwestern University.
| Reprints not available from the authors.