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Gluten intake and risk of psoriasis, psoriatic arthritis, and atopic dermatitis among United States women - 11/02/20

Doi : 10.1016/j.jaad.2019.08.007 
Aaron M. Drucker, MD, ScM a, b, c, , Abrar A. Qureshi, MD, MPH c, d, e, f, Jordan M. Thompson, MD c, Tricia Li, MD, MS c, f, Eunyoung Cho, ScD c, e, f
a Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada 
b Women's College Research Institute and Division of Dermatology, Department of Medicine, Women's College Hospital, Toronto, Canada 
c Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island 
d Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island 
e Department of Epidemiology, School of Public Health, Brown University, Providence, Rhode Island 
f Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 

Correspondence to: Aaron M. Drucker, MD, ScM, Women's College Hospital, 76 Grenville St, Toronto, ON M5S1B2, Canada.Women's College Hospital76 Grenville StTorontoONM5S1B2Canada

Abstract

Background

Associations between gluten intake and psoriasis, psoriatic arthritis, and atopic dermatitis are poorly understood.

Objective

To determine whether increased gluten intake is associated with incident psoriasis, psoriatic arthritis, and atopic dermatitis.

Methods

Cohort studies among women in Nurses' Health Study II. Food frequency questionnaires were used to calculate gluten content of participants' diet every 4 years (1991-2015 for psoriatic disease, 1995-2013 for atopic dermatitis). Disease outcomes were assessed by self-report and subsequently validated. Multivariable-adjusted Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for the association between gluten intake (quintiles) and psoriasis, psoriatic arthritis, and atopic dermatitis.

Results

We included 85,185 participants in the psoriasis analysis, 85,324 in the psoriatic arthritis analysis, and 63,443 in the atopic dermatitis analysis. Increased gluten intake was not associated with any of the outcomes (all P for trend >.05). Comparing highest and lowest gluten intake quintiles, the multivariable hazard ratios (95% confidence intervals) were 1.15 (0.98-1.36) for psoriasis, 1.12 (0.78-1.62) for psoriatic arthritis, and 0.91 (0.66-1.25) for atopic dermatitis.

Limitations

No assessment of a strictly gluten-free diet.

Conclusions

Our findings do not support the amount of dietary gluten intake as a risk factor for psoriasis, psoriatic arthritis, or atopic dermatitis in adult women.

Le texte complet de cet article est disponible en PDF.

Key words : atopic dermatitis, diet, gluten, psoriasis, psoriatic arthritis

Abbreviations used : CI, HR, NHSII, PASE, PST


Plan


 Funding sources: This study was funded by the Brown University Department of Dermatology and an investigator-initiated grant from Regeneron and Sanofi to Dr Qureshi, and a Nurses' Health Study II National Institutes of Health National Cancer Institute grant (UM1-CA-176726).
 Conflicts of interest: In the last 3 years, Dr Drucker has served as an investigator and has received research funding from Sanofi and Regeneron and has been a consultant for Sanofi, RTI Health Solutions, Eczema Society of Canada, and Canadian Agency for Drugs and Technology in Health. He has received honoraria from Prime Inc, Spire Learning, CME Outfitters, Eczema Society of Canada, and the Canadian Dermatology Association. His institution has received educational grants from Sanofi and AbbVie. Dr Qureshi reports personal fees from AbbVie, Amgen, Centers for Disease Control and Prevention, Janssen, Pfizer, and Novartis as a consultant, and personal fees from Regeneron and Sanofi as an investigator. All honoraria are donated to charity. Drs Thompson, Li, and Cho do not report any recent or relevant disclosures.
 An earlier iteration of the results related to psoriatic disease only was presented as an abstract at the Society for Investigative Dermatology Annual Meeting, Scottsdale, AZ, May, 11-14, 2016.
 Reprints are not available from the authors.


© 2019  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 82 - N° 3

P. 661-665 - mars 2020 Retour au numéro
Article précédent Article précédent
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