While cutaneous melanomas (CM) account for greater than 90% of all melanomas, noncutaneous melanomas (NCM) are more aggressive and associated with worse outcomes. The shared progenitor cell type among CM and NCM suggests that patients with a history of CM may be at higher risk for subsequent NCM.
To determine whether patients with a history of CM demonstrate an increased risk of second primary cutaneous, ocular, oral, or vaginal/exocervical melanoma compared with the general population.
This was a population-based retrospective cohort study using the Surveillance, Epidemiology, and End Results database. We calculated standardized incidence ratios (SIRs) and excess absolute risks of second primary cutaneous, ocular, oral, and vaginal/exocervical melanoma in patients with a history of CM.
Patients with prior CM (n = 169,841) were more likely than the general population to develop a second primary CM (SIR, 8.17; 95% confidence interval [CI], 8.01-8.33), ocular melanoma (SIR, 1.99; 95% CI, 1.54-2.53), oral melanoma (SIR, 6.87; 95% CI, 2.23-16.04), and vaginal/exocervical melanoma (SIR, 10.17; 95% CI, 4.65-19.30).
This study is limited by possible under-reporting of CM in cancer registries.
In caring for patients with a history of CM, physicians should be vigilant not only about risk of recurrence but also about second primary CM and NCM.Le texte complet de cet article est disponible en PDF.
Key words : cutaneous melanoma, melanoma, noncutaneous melanoma, screening, second primary melanoma, Surveillance, Epidemiology, and End Results program
Abbreviations used : BRAF, CI, CM, GNA11, GNAQ, HMB-45, KIT, MART-1, MITFL, NCM, NRAS, SEER, SIR, SOX10, US
| Funding sources: None.
| Conflicts of interest: None disclosed.
| Prior presentations: American Academy of Dermatology 2019 Annual Meeting, Washington, DC, March 1-5, 2019; and American College of Mohs Surgery (ACMS) 51st Annual Meeting, Baltimore, Maryland, May 2-5, 2019.
| IRB approval status: Exempt.
| Reprints not avilable from the authors.