Several studies have found that the microbiota of psoriatic lesions is different from that of healthy skin.
To characterize the microbiota of lesional and unaffected skin in patients with psoriasis and controls and investigate the correlation between cutaneous microbiota and clinical features of psoriasis.
Using quantitative polymerase chain reaction and 16S rRNA sequencing, we assayed the profiles of cutaneous microbiota in controls, unaffected skin, and psoriatic lesions. We also investigated the correlation of psoriasis-associated taxa with clinical characteristics.
High bacterial load was identified in the psoriatic lesions compared with unaffected skin and controls. There was an imbalance between Cutibacterium (also known as Propionibacterium) and Corynebacterium in psoriatic skin. Lesions showed a higher proportion of Corynebacterium and a lower proportion of Cutibacterium compared with unaffected skin and controls. Corynebacterium was correlated with the severity of local lesions, whereas Cutibacterium showed correlation with the abnormity of skin capacitance.
We did not conduct a longitudinal study.
Psoriatic lesions are characterized by higher bacterial load and imbalance between Cutibacterium and Corynebacterium.Le texte complet de cet article est disponible en PDF.
Key words : bacterial load, Corynebacterium, Cutibacterium, psoriasis
Abbreviations used : CAP, Cr, Cu, FDR, PASI, PCR, ROC curve
| Drs Quan and Chen contributed equally to this work.
| Funding sources: This work was supported by Special Fund of National Excellent Doctoral Dissertation (201479), China Postdoctoral Science Foundation (2015M571577), National Natural Science Foundation of China (91442123 and 81502718), and Foundation of National Clinical Key Department Construction Project (2012649).
| Conflicts of interest: None disclosed.
| Reprints not available from the authors.