Telbivudine has been proved effective in preventing mother-to-child transmission.
The immunological mechanism of antiviral treatment is explored.
The proportion of regulatory T cells was decreased in neonates of treatment group.
Maternal use of telbivudine may be useful in regulating neonatal immune function.
Antiviral treatment could block mother-to-child transmission (MTCT) of hepatitis B virus (HBV) effectively. We examined whether maternal use of telbivudine (LdT) could decrease the proportion of CD4+CD25+ regulatory T cells and explored the immunological mechanism. A total of 89 pregnant women with HBsAg positive were enrolled, where 30 pregnant women with HBeAg negative (viral load<106 IU/ml) and the other 59 pregnant women with HBeAg positive (viral load≥106 IU/ml) were followed in the study. The women with high viral load were divided to the LdT-treated group where they were prescribed with 600mg LdT daily (29 cases) during the third trimester of pregnancy or to the non-treated group (30 cases) on a voluntary basis. Samples of neonates were taken for analyzing CD4+CD25+ Tregs with flow cytometric techniques. A more significant decrease in the proportion of CD4+CD25+Tregs in neonatal peripheral blood had been observed with maternal use of telbivudine (2.8%±1.1%) than those without any treatment (7.0%±1.6%, P< 0.01). None of the infants in the LdT-treated group were HBsAg positive at 7 months of age. In addition, neonates whose mothers received telbivudine had a significant improvement in cellular immune function, as indicated by the proportion of CD8+ T cells. For HBV carriers with high viral load, maternal use of LdT may be useful in regulating neonatal immune function involved in mother-to-child transmission of hepatitis B virus.Le texte complet de cet article est disponible en PDF.
Keywords : Telbivudine, T-Lymphocytes, Hepatitis B virus, Mother-to-child transmission
Vol 44 - N° 2P. 195-203 - avril 2020 Retour au numéro
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