Porogen Effect on Structural and Physical Properties of ?-TCP Scaffolds for Bone Tissue Regeneration - 26/05/20

Doi : 10.1016/j.irbm.2020.05.007

C. Ruiz-Aguilar ^a,^{^⁎} , U. Olivares-Pinto ^a, R.A.L. Drew ^b, E.A. Aguilar-Reyes ^c, I. Alfonso ^d
^a Escuela Nacional de Estudios Superiores Unidad Juriquilla, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Boulevard Juriquilla 3001, CP 76230, Santiago de Querétaro, Qro., Mexico
^b Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, 1455 Maisonneuve Blvd West, Montreal, QC, H3G 1M8, Canada
^c Instituto de Investigación en Metalurgia y Materiales, Universidad Michoacana de San Nicolás de Hidalgo, Av. Francisco J. Múgica S/N, CP 58030, Morelia, Mich., Mexico
^d Instituto de Investigaciones en Materiales, Unidad Morelia, Universidad Nacional Autónoma de México, Antigua Carretera a Pátzcuaro 8701, Ex-Hacienda San José de la Huerta, CP 58190, Morelia, Mich., Mexico

^⁎Corresponding author.

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Graphical abstract

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Highlights

•	β-Tricalcium phosphate scaffolds were performed using sucrose in different amounts (50, 60 and 70 wt.%).
•	Ethanol was used to dissolve the sucrose before the scaffold was sintering.
•	The scaffolds with 50 and 60% of sucrose presented excellent results of porosity, pore size and surface area.

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Abstract

Scaffolds for bone tissue applications have been an outstanding alternative to repair and regenerate bone tissue defects caused by traumas or illness. There are many methods available to fabricate porous scaffold such as solvent casting, gas bubble, phase separation, electrospinning, particle-leaching, among others. The particle-leaching technique has shown advantages in bone tissue regeneration applications, the main benefit of this technique is related to the porogen particle size and the porogen content in the manufacture of scaffolds. Tricalcium phosphate is one calcium phosphate that presented appropriated characteristic to be used for bone tissue engineering due to the chemical properties similar to the human bones. Scaffolds of tricalcium phosphate β phase were made using sugar particles. The porogen was varied in amounts of 50, 60 and 70 wt.% of two commercial sugars with the remainder of the composition made up of tricalcium phosphate powders. The pore sizes in all the scaffolds were in the range of 90 to 600 μm with an irregular pore morphology and the porosity was in the range of 63 to 77%.

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Keywords : Calcium phosphate, Scaffold, Bone, Porogen leaching, Sugar