Alteration of blood inflammation and glutamate level in parietal precuneus cortex within patients with recent history of suicide attempt: A study of magnetic resonance spectroscopy - 29/05/20
Résumé |
Suicidal behavior (SB) has been associated with structural and functional impairments in neuroimaging studies and with an increase of peripheral inflammation. We assumed that the increased level of peripheral inflammation markers could be correlated with some abnormalities of brain metabolites in areas involved in suicidal vulnerability such as the anterior and posterior cingulate gyrus cortex (ACC and PCC), the orbito-frontal cortex (OFC) and parietal precuneus cortex (PPC). This hypothesis has been tested by studying the association between levels of 6 cerebral metabolites [i.e. Glutamate (Glu), glutamine (Gln), N-Acetyl aspartate (TNAA), Myo-inositol (Myo)…], 15 biomarkers of inflammation (i.e.C reactive protein (CRP), interleukin (IL) 2, IL1β, IL6, RANTES…) and 8 clinical variables known to be involved in suicidal vulnerability (i.e. depression, childhood trauma, impulsivity, suicidal ideation…). Sixty-six participants were recruited and divided into three groups: 21 depressed patients with a recent SA (<8 days), 23 affective controls (depressed patients without lifetime history of SA) and 22 healthy controls. Following a clinical assessment, they performed a Proton magnetic resonance spectroscopy to measure the levels of 6 cerebral metabolites (Fig. 1). A blood sample was collected to measure peripheral inflammation. We found a higher level of C reactive protein (CRP) in suicide attempters than in both affective controls and healthy controls. CRP level was negatively correlated with concentrations of Glutamate (R=−0.30 P<0.01) in the PPC. We found a decrease of TNAA concentration in the ACC and an increase of Myo concentration in the PCC in both suicide attempters and affective controls vs healthy controls. However, this difference remains significant only for affective controls vs healthy controls. In the ACC, Glu concentration was significantly positively correlated with peripheral inflammatory markers (CD40L, IL1b, IL2, IL4, IL6, IL10, IL1a and TNFα) (R>40% P<0.001). Finally, we found a negative correlation between Glu concentration and depression severity (R=−0.24562 P=0.0486). In conclusion, our main result showed a decrease of glutamate level in PPC link to an increase of peripheral CRP level in SA. Those results suggest new tracks of comprehension of physiopathology of SB.
Le texte complet de cet article est disponible en PDF.Keywords : Magnetic resonance spectroscopy, Inflammation, Suicidal behavior, Neuroimaging, Glutamate, N acetyl aspartate
Plan
Vol 1 - N° S2
P. S111-S112 - décembre 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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