Today, a gap persists between subjects with schizophrenia and general population, especially in terms of life expectancy and quality of life. Life expectancy is an epidemiological variable referring to mortality. The WHO's definition of quality of life is the most used in literature: individuals’ perceptions of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns [1 Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL Group Psychol Med 1998 ;  28 (3) : 551-558

Cliquez ici pour aller à la section Références].

We conducted a narrative review of the literature with the following key words: “life expectancy”, “quality of life” and “schizophrenia”. We mainly used the PubMed database for our researches.

The mortality is higher in subjects with schizophrenia compared to general population. A recent systematic review and meta-analysis showed that the average life expectancy was 64.7 years with an average of 14.5 years of potential life lost. Moreover, this gap concerning life expectancy persisted over time [2Hjorthoj C., Sturup A.E., McGrath J.J., Nordentoft M. Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis Lancet Psychiatry 2017 ;  4 (4) : 295-301 [cross-ref]

Cliquez ici pour aller à la section Références]. Natural death is the first cause of mortality in schizophrenia with cardiovascular mortality at the leading cause. The quality of life is significantly lower compared to general population [3Medici C.R., Vestergaard C.H., Hjorth P., Hansen M.V., Shanmuganathan J.W.D., Viuff A.G., et al. Quality of life and clinical characteristics in a nonselected sample of patients with schizophrenia Int J Soc Psychiatry 2016 ;  62 (1) : 12-20 [cross-ref]

Cliquez ici pour aller à la section Références]. Depressive symptoms are its strongest factors.

Schizophrenia is associated with a decreased life expectancy and a low quality of life. Taking into account these two aspects of life is fundamental in care of subjects with schizophrenia. Therefore, it is urgent to treat cardiovascular comorbidities and depression in order to improve life expectancy and quality of life in these patients.