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Non-coding RNAs in drug resistance of head and neck cancers: A review - 30/05/20

Doi : 10.1016/j.biopha.2020.110231 
Fengsheng Dai a, b, 1, Li Dai a, b, 1, Xiwang Zheng a, c, 1, Yujia Guo a, c, Yuliang Zhang a, c, Min Niu a, c, Yan Lu d, Huizheng Li e, Rui Hou f, Yu Zhang g, h, Shuxin Wen c, i, Wanglai Hu j, Changming An k, , Yongyan Wu a, b, c, l, , Wei Gao a, b, c, g, m,
a Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China 
b Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China 
c Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China 
d Department of Otolaryngology Head & Neck Surgery, The First Hospital, Jinzhou Medical University, Jinzhou, 121001, Liaoning, PR China 
e Department of Otolaryngology Head & Neck Surgery, Dalian Municipal Friendship Hospital, Dalian Medical University, Dalian, 116100, Liaoning, PR China 
f Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, 6009, Australia 
g Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China 
h Department of Physiology, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China 
i Department of Otolaryngology Head & Neck Surgery, General Hospital of Shenzhen University, Shenzhen, 518055, Guangdong, PR China 
j School of Basic Medical Science, Anhui Medical University, He Fei, 230032, Anhui, PR China 
k Department of Head and Neck Surgery, Cancer Hospital, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, PR China 
l Department of Biochemistry & Molecular Biology, School of Basic Medical Science, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China 
m Yiducloud’s Institute of Medical Data Science, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China 

Corresponding author at: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China.Shanxi Key Laboratory of Otorhinolaryngology Head and Neck CancerShanxi Medical UniversityTaiyuanShanxi030001PR China⁎⁎Corresponding author.

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Highlights

miRNAs mainly affect HNC drug resistance by influencing the expression of their target mRNAs and by regulating apoptosis pathways, EMT, and CSCs.
lncRNAs are widely involved in HNC resistance to cisplatin, paclitaxel, 5-fluorouracil, and doxorubicin.
circRNAs may have an important regulatory role in the mechanism of tumor resistance in HNCs.
Non-coding RNAs have crucial roles in HNC drug resistance and provide novel insights into HNC therapeutic resistance.

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Abstract

Head and neck cancer (HNC), which includes epithelial malignancies of the upper aerodigestive tract (oral cavity, oropharynx, pharynx, hypopharynx, larynx, and thyroid), are slowly but consistently increasing, while the overall survival rate remains unsatisfactory. Because of the multifunctional anatomical intricacies of the head and neck, disease progression and therapy-related side effects often severely affect the patient’s appearance and self-image, as well as their ability to breathe, speak, and swallow. Patients with HNC require a multidisciplinary approach involving surgery, radiation therapy, and chemotherapeutics. Chemotherapy is an important part of the comprehensive treatment of tumors, especially advanced HNC, but drug resistance is the main cause of poor clinical efficacy. The most important determinant of this phenomenon is still largely unknown. Recent studies have shown that non-coding RNAs have a crucial role in HNC drug resistance. In addition, they can serve as biomarkers in the diagnosis, treatment, and prognosis of HNCs. In this review, we summarize the relationship between non-coding RNAs and drug resistance of HNC, and discuss their potential clinical application in overcoming HNC chemoresistance.

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Keywords : Head and neck cancer, Non-coding RNA, MicroRNA, Long non-coding RNA, Circular RNA, Drug resistance, Chemoresistance


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Vol 127

Article 110231- juillet 2020 Retour au numéro
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