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A review on ameliorative green nanotechnological approaches in diabetes management - 30/05/20

Doi : 10.1016/j.biopha.2020.110198 
Monika Bhardwaj a , Poonam Yadav a , Sunita Dalal b , Sudhir Kumar Kataria a,
a Department of Zoology, Maharshi Dayanand University, Rohtak, 124001, Haryana, India 
b Department of Biotechnology, Kurukshetra University, Kurukshetra, 136118, Haryana, India 

Corresponding author.

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Graphical abstract

Managerial pathways showing anti-diabetic action of different metallic nanoparticles (A) flavonoids and glycosides coated MNPs (B) Terpenoids and flavonoids coated MNPs (C) MNPs inhibits the α-amylase and α-glucosidase.




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Highlights

Diabetes mellitus is a chronic metabolic disorder due to hyperglycaemic condition mainly due to insufficient insulin secretion or body fails to respond to secreted insulin from pancreatic cells and is the third cause of death worldwide after cardiovascular diseases and cancer.
Nanotechnology is an emerging area in pharmaceutical sciences as nanoparticles mainly silver, zinc oxide, gold, chitosan etc synthesized using different plant resources as various secondary metabolites like saponins, flavonoids, steroids, alkaloids, and tannins, increases the efficacy of drugs by their target specific activity and play pivotal role in management of disease.
The green metallic nanotechnological approaches revealed antibiabetic potential and assisted in understanding various therapeutic processes and manipulated significantly regulatory mechanism/s pertaining to management of diabetes through pancreatic α-amylase, intestinal α-glucosidase, insulin secretion or its action, glucose uptake, receptor affinity and other biochemical/histological parameters in different in vivo and in vitro systems.
The furtherance of nanotechnological approaches about exploration of herbal chemical potential may lead to consideration of certain novel magic drug molecules for better management of diabetes and other diseases.
The nanotechnology is expanding its wings to cater its beneficial effects in fields like drug delivery system, cosmetics, agriculture, tissue engineering, diagnostic systems, and management of various diseases.

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Abstract

Diabetes mellitus is a chronic metabolic disorder which results in increase of blood glucose level mainly due to insufficient insulin secretion or body fails to respond to secreted insulin from pancreatic cells. Diabetes is mainly the third cause of death worldwide after cardiovascular diseases and cancer. Nanotechnology is an emerging area in pharmaceutical sciences as nanoparticles are reported to increase the efficacy of drugs derived from plant resources by their target specific activity. The nanomaterials synthesized from plant resources have regulatory potential in control of certain diseases with minimum or no side effects. The review focuses on the reported antidiabetic potential of different metallic and other nanoparticles mainly silver, zinc oxide, gold, copper, selenium, chitosan and iron oxide, synthesized using different plant resources as various secondary metabolites like saponins, flavonoids, steroids, alkaloids, tannins. The green nanotechnological approach reported their antibiabetic potential as magic molecules in understanding various therapeutic processes and manipulated significantly regulatory mechanism/s pertaining to management of diabetes through pancreatic α-amylase, intestinal α-glucosidase, insulin action, glucose uptake in different in vivo and in vitro systems. The additional inputs of nanotechnological approaches regarding further exploration of herbal chemical potential may lead to consideration of certain novel magic drug molecules and may act as an advantage in management of diabetes for betterment of mankind.

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Keywords : Diabetes, nanoparticles, secondary metabolites, α-amylase, insulin, glucose uptake assays


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Vol 127

Article 110198- juillet 2020 Retour au numéro
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