Beneficial effects of polysaccharide-rich extracts from Apocynum venetum leaves on hypoglycemic and gut microbiota in type 2 diabetic mice - 30/05/20
pages | 9 |
Iconographies | 6 |
Vidéos | 0 |
Autres | 0 |
Graphical abstract |
Polysaccharide-rich extracts from Apocynum venetum leaves have beneficial effects on management of type 2 diabetes by attenuating hypoglycemic and modulating gut microbiota in mice.
Highlights |
• | Polysaccharide-rich extracts from Apocynum venetum leaves were obtained. |
• | Polysaccharide extracts had significant anti-hypoglycemic effects in diabetes rats. |
• | Polysaccharide extracts could modulate the gut microbiota in diabetes rats. |
• | Polysaccharide extracts may be used as prebiotics for management of type 2 diabetes. |
Abstract |
Diabetes is one of the most concerned metabolic diseases worldwide and threaten public health. In the present work, two polysaccharide-rich extracts from Apocynum venetum leaves were extracted using distilled water and alkaline solution (0.05 M NaOH), and fully characterized. Hypoglycemic and hypolipidemic effects of two polysaccharide-rich extracts on high-fat diet and streptozocin-induced type 2 diabetic mice were investigated. Treatment of alkaline extracted polysaccharide-rich products significantly decreased the levels of fasting blood glucose, serum insulin, glycated serum protein, as well as serum lipids profiles including total cholesterol, triacylglycerols, low-density lipoprotein cholesterol, and nonesterified fatty acid. Meanwhile, the reduced glycogen contents in liver were prominently improved, and the oxidative damage were markedly ameliorated by alkaline extracted polysaccharide products in diabetic mice. Furthermore, both polysaccharide-rich extracts could reverse the gut microbiota dysbiosis in diabetic mice by increasing the abundance of genera Odoribacter, Anaeroplasma, Parasutterella, and Muribaculum; while by decreasing the abundance of genera Enterococcus, Klebsiella, and Aerococcus. This study provides new sights for exploitation of Apocynum venetum extracts as a promising anti-diabetic nutraceutical for the treatment of type 2 diabetes and metabolic syndrome.
Le texte complet de cet article est disponible en PDF.Keywords : Polysaccharide, Apocynum venetum, Diabetes, Hypoglycemic, Gut microbiota
Plan
Vol 127
Article 110182- juillet 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?