Médecine

Paramédical

Autres domaines


S'abonner

Effects of umbelliferone isolated from the Ferulago pauciradiata Boiss. & Heldr. Plant on cecal ligation and puncture-induced sepsis model in rats - 30/05/20

Doi : 10.1016/j.biopha.2020.110206 
Z. Kutlu a, , M. Celik b , A. Bilen c , Z. Halıcı d, e , S. Yıldırım f , S. Karabulut g , S. Karakaya h , Delimustafaoğlu F. Bostanlık i , P. Aydın j
a Department of Biochemistry, Faculty of Pharmacy, Atatürk University, Erzurum, 25240, Turkey 
b Department of Biochemistry, Faculty of Medicine, Atatürk University, Erzurum, 25240, Turkey 
c Department of Internal Medicine, Faculty of Medicine, Atatürk University, Erzurum, 25240, Turkey 
d Faculty of Medicine, Department of Pharmacology, Atatürk University, Erzurum, 25240, Turkey 
e Clinical Research, Development and Design Application and Research Center, Ataturk University, 25240, Erzurum, Turkey 
f Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, 25240, Turkey 
g Health Services Vocational School, Bayburt University, Bayburt, 69000, Turkey 
h Department of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Erzurum, 25240, Turkey 
i Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University, Ankara, 06000, Turkey 
j Department of Anesthesia, Regional Education and Research Hospital, Erzurum, 25240, Turkey 

Corresponding Author at: Department of Biochemistry, Faculty of Pharmacy, Atatürk, Turkey.Department of BiochemistryFaculty of PharmacyAtatürkTurkey

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

pages 15
Iconographies 19
Vidéos 0
Autres 0

Graphical abstract




Le texte complet de cet article est disponible en PDF.

Highlights

UF has a strong antioxidant and anti-inflammatory effect on sepsis.
UF was ameliorative LPS-induced TNF-α, IL-1β, and NF-κB mRNA expression.
UF has a protective effect against acute lung, kidney and liver damage CLP-induced sepsis model.
UF may represent a new treatment for the organ dyfunction.

Le texte complet de cet article est disponible en PDF.

Abstract

Sepsis is a pathophysiological event involving systemic inflammatory response syndrome, multiple organ failure syndromes, and tissue damage. Overproduction of free radicals as a result of tissue damage during sepsis contributes to cellular toxicity, organ failure, and even mortality. Antioxidants, which scavenge free radicals, play a protective role against various diseases. Previous studies have shown that umbelliferone (UF) has antioxidant and anti-inflammatory effects. Since oxidative stress is naturally associated with sepsis-induced organ dysfunction, the application of antioxidant compounds could potentially illuminate the pathophysiology of sepsis, which does not yet have an effective treatment.

The sepsis model induced by cecal ligation and puncture (CLP) was applied to rats. Different doses of UF (10░mg/kg, 20░mg/kg, and 40░mg/kg) on oxidant-antioxidant in septic rats, mRNA of inflammatory mediators such as tumor necrosis factor- α (TNF-α) and interleukin (IL)-1 its effects on expression levels were evaluated in lung, kidney, and liver tissues.

When the lung, kidney, and liver tissues of septic rats were compared with those of the control group, it was found that UF administration increased dose-dependent superoxide dismutase activity and glutathione levels and significantly decreased malondialdehyde levels. The effects of UF administration on oxidative parameters were dose-dependent. The 40░mg/kg UF dose showed greater anti-oxidative properties than the 20░mg/kg and 10░mg/kg doses for all the evaluated parameters. Further, the TNF- α mRNA expression of the CLP +40░mg/kg group was reduced to a level comparable to that of the control group.

UF has been found to be an effective molecule in reducing oxidative stress by supporting endogenous antioxidants and enhancing the scavenging effects of free radicals. The potent antioxidant property of UF may also be related to the suppression of the cytokine cascade during sepsis. The results suggest that UF administration may represent a new treatment for the prevention of lung, kidney and liver damage caused by septic conditions.

Le texte complet de cet article est disponible en PDF.

Keywords : Antioxidant, CLP, IL-1, TNF-α, Umbelliferone


Plan


© 2020  Publié par Elsevier Masson SAS.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 127

Article 110206- juillet 2020 Retour au numéro
Article précédent Article précédent
  • Quercetin Dihydrate inhibition of cardiac fibrosis induced by angiotensin II in vivo and in vitro
  • Liang Wang, Aiping Tan, Xiangbo An, Yunlong Xia, Yunpeng Xie
| Article suivant Article suivant
  • A review for physiological activities of EGCG and the role in improving fertility in humans/mammals
  • Yangbo Zhang, Haiyan Lin, Changwei Liu, Jianan Huang, Zhonghua Liu

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.

Déjà abonné à cette revue ?

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.