The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway - 30/05/20
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Graphical abstract |
Highlights |
• | Resveratrol stimulates the Nrf2 signaling through blockage of Keap1. |
• | Resveratrol has protective effects against various diseases through Nrf2 siganling activation. |
• | Res ameliorates oxidative stress, apotosis and inflammatory indexes in several tissues. |
Abstract |
Resveratrol is a natural polyphenol derived from grapes, berries, red wine, peanuts amongst other fruits and nuts. Beneficial effects such as anti-inflammatory, antioxidant, hepatoprotective, neuroprotective, cardioprotective, renoprotective, anti-obesity, anti-diabetic, and anti-cancer of resveratrol have been demonstrated by preclinical and clinical research. A possibility is that these therapeutical effects are associated with modulation of the Nrf2 signaling pathway in the following way: resveratrol may potentiate Nrf2 signaling through blockage of Keap1, by means of changing the Nrf2 mediators, its expression and its nuclear translocation. This article reviews the evidence of the Nrf2 modulating hypothesis as a possible molecular mechanism underlying the medicinal properties of resveratrol.
Le texte complet de cet article est disponible en PDF.Keywords : Resveratrol, Nrf2, Therapeutic effects, Oxidative stress, Inflammation
Plan
Vol 127
Article 110234- juillet 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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