Blepharospasm, dry eye and extractable nuclear antigen antibodies - 10/06/20

Doi : 10.1016/j.jfo.2020.06.001

B.C. Girard ^a,^b,⁎ , M. Abdellaoui ^a,^b, G. de Saint Sauveur ^a,^b, A. Huang ^a,^b, P. Lévy ^c,^d
^a Service d’ophtalmologie, hôpital Tenon, Assistance publique–Hôpitaux de Paris, 4, rue de-la-Chine, 75970 Paris cedex 20, France
^b UPMC Sorbonne université, Paris, France
^c Département de santé publique, hôpital Tenon, Assistance publique–Hôpitaux de Paris, 4, rue de-la-Chine, 75970 Paris cedex 20, France
^d INSERM, institut Pierre-Louis de santé publique, UPMC Sorbonne université, Paris, France

^⁎Corresponding author at: Service d’ophtalmologie, hôpital Tenon, assistance publique–hôpitaux de Paris, 4, rue de-la-Chine, 75970 Paris cedex 20, France.Service d’ophtalmologie, hôpital Tenon, assistance publique–hôpitaux de Paris4, rue de-la-ChineParis cedex 2075970France

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Summary

Purpose

To study whether there is an association between benign essential blepharospasm and Sjögren's syndrome by analyzing the presence of antibodies to extractable nuclear antigens in this population.

Methods

Seventy-two patients with benign essential blepharospasm (BEB) were included in this study. We excluded patients with hemifacial spasm or blepharospasm secondary to known corneal pathology. We recorded results of Schirmer I testing as well as levels of anti-SSA/Ro and anti-SSB/La antibodies.

Results

Our study included 72 patients (144 eyes), of which 62 (86.1%) were women. The mean age was 74.3±10.73 years. The mean Schirmer I test result was 3.14±4.00mm. Five women (8% of this female population) were found to have positive anti-SSA/Ro and anti-SSB/La antibodies. Their mean age was 65.66±13.24 years, while the mean age of the antibody-negative patients was 75.42±9.27 years. There was no statistically significant difference between the Schirmer I tests of the antibody positive and negative patients.

Conclusion

This study demonstrates a possible association between Sjögren's syndrome and benign essential blepharospasm, justifying anti-SSA/Ro and anti-SSB/La testing in these patients.

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Keywords : Blepharospasm, Gougerot-Sjögren Syndrome, Dry eye syndrome, Dry eye, Schirmer's test, Extractable nuclear antigen antibodies, Anti-SSA/Ro antibodies, Anti-SSB/La antibodies, Botulinum toxin A