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Concurrence of HBV infection and non-alcoholic fatty liver disease is associated with higher prevalence of chronic kidney disease - 19/07/20

Doi : 10.1016/j.clinre.2020.06.009 
Su Lin a, Mingfang Wang b, Yuxiu Liu b, Jiaofeng Huang b, Yinlian Wu b, Yueyong Zhu b, Xiaozhong Wang a,
a Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou, Fujian 
b Liver Research Center of the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350000, China 

Corresponding author at: Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou, Fujian, China.Department of Gastroenterology, Union Hospital of Fujian Medical University, FuzhouFujianChina
Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Sunday 19 July 2020
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Highlights

This population-based study accessed the impact of HBV infection and /or non-alcoholic fatty liver disease (NAFLD) on chronic kidney disease (CKD). The results showed:.
Both HBV-infection and NAFLD increase the risk of CKD.
The impact of HBV-infection on kidney is stronger than NAFLD.
Co-existence of HBV-infection and NAFLD increased the risk of CKD by 2-fold compared to patients without liver disease,
Monitoring and control of CKD in patients with chronic liver disease are strongly recommended.

Le texte complet de cet article est disponible en PDF.

Summary

Aims

Coexistence of non-alcoholic fatty liver disease (NAFLD) and hepatitis B virus (HBV) infection is common in clinical practice. This study was to explore the prevalence of chronic kidney disease (CKD) in patients with NAFLD and/or HBV.

Methods

Participants who received health examination in a physical examination center were included in this cross-sectional study. Binary logistic regression was used to estimate the odds ratios (ORs) for CKD.

Results

A total of 32,578 cases were included in the final analysis, with 52.3% males and an average age of 44.01±13.09 years old. The positive rate of HBV surface antigen was 14.5% and NAFLD was diagnosed in 30.2% cases. The coexistence of NAFLD and HBV-infection was found in 1,275 (3.9%) cases. In overall population, 713 (2.2%) cases were diagnosed with CKD. The CKD prevalence were 1.4%, 2.1%, 3.5% and 5.0% in those without NAFLD or HBV, HBV-infection alone, NAFLD alone and those with concomitant HBV-infection and NAFLD, respectively. After adjustment for age, sex, body mass index, diabetes and hypertension, the correlation between CKD and liver disease was still significant in HBV group (OR=1.388, 95%CI: 1.055–1.809), yet no longer existed in patients with NAFLD (OR=1.183, 95%CI: 0.986–1.420). The concomitant of NAFLD and HBV infection was associated with a higher odds ratio for CKD compared to any other group (OR=1.961, 95%CI=1.454–2.645).

Conclusions

The coexistence of NAFLD and HBV increases the risk of CKD by 2-fold. The control of multiple liver diseases will be beneficial not only to liver but also to kidney.

Le texte complet de cet article est disponible en PDF.

Keywords : Non-alcoholic fatty liver disease, Hepatitis B virus, Chronic kidney disease


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