Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19 - 19/07/20

Doi : 10.1016/j.accpm.2020.06.006

Emmanuel Dudoignon ^a,^c,^{^{1
These authors contributed equally to this work.}}, Nabila Moreno ^b,^{^{1
These authors contributed equally to this work.}}, Benjamin Deniau ^a,^e, Maxime Coutrot ^a, Romain Longer ^b, Quentin Amiot ^b, Alexandre Mebazaa ^a,^c, Romain Pirracchio ^d, François Depret ^a,^c, Matthieu Legrand ^a,^c,^d,^{^{1
These authors contributed equally to this work.},}⁎
^a Assistance Publique–Hôpitaux de Paris (AP–HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France
^b Assistance Publique–Hôpitaux de Paris (AP–HP), Groupe Hospitalier St Louis-Lariboisière, Department of Biochemistry, Paris, France
^c University of Paris, Paris, France
^d Department of Anesthesiology and Peri-operative Medicine and Critical Care Medicine, University of California, San Francisco, California
^e Inserm UMR-S 942, Mascot, Lariboisière Hospital, Paris, France

^⁎Corresponding author at: University of California San Francisco Memory and Aging Center, Department of Anesthesiology and Peri-operative Care, 500, Parnassus Avenue, San Francisco, United States.University of California San Francisco Memory and Aging Center, Department of Anaesthesiology and Peri-operative Care500, Parnassus AvenueSan FranciscoUnited States

connectez-vous ou créez un compte

Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.

Connectez-vous pour en bénéficier!

Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Sunday 19 July 2020
Cet article a été publié dans un numéro de la revue, cliquez ici pour y accéder

Abstract

The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. SARS-CoV-2 has been suggested to modulate the renin-angiotensin-aldosterone system (RAAS). In this series of COVID-19 critically ill patients, we report evidence of activation of the RAAS in COVID-19 patients with AKI.

Le texte complet de cet article est disponible en PDF.

Keywords : Renin-angiotensin-aldosterone system, COVID-19