A systematic approach on the frequency of cleft lip/palate in pediatric patients with leukemia - 19/07/20

Doi : 10.1016/j.jormas.2020.06.012

D.A. Prodan ^a, S. Bran ^a, C. Dinu ^a, G. Baciut ^a, C. Tomuleasa ^b, A. Piciu ^c, H. Opris ^a, A. Mester ^d,⁎ , M. Baciut ^a
^a Department of Maxillofacial Surgery and Implantology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania
^b Department of Hematology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania
^c Department of Medical Oncology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania
^d Department of Oral Health, University of Medicine and Pharmacy “Iuliu Hatieganu”, 15 Victor Babes Street, Cluj-Napoca, 400012, Romania

^⁎Corresponding author.

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Abstract

Purpose

The purpose of this study was to reveal the frequency between cleft lip/palate and leukemia in pediatric patients by a systematic analysis of the current literature.

Materials and methods

Electronic search on three database (PubMed, Web of Science, Cochrane) was carried out using the following keywords: cleft lip, cleft palate, facial cleft, oral cleft, orofacial cleft, leukemia, acute myeloid leukemia, acute lymphocytic leukemia, lymphoma. Studies published until March 2020 reporting an association between leukemia and cleft lip/palate (CL/P) were included in our research.

Results

Five articles (2 case-controls, 3 cohorts), met the inclusion criteria. Case-control studies involved 268 patients with acute lymphocytic leukemia (ALL) and 177 patients with acute myeloid leukemia (AML), of which 9 patients had CL/P. The cohorts studies involved 10 patients with ALL, of which 6 patients with CL/P, 2 patients with cleft palate and 1 patient with cleft lip and palate.

Conclusion

This research was able to indicate a limited evidence of the association between CL/P and leukemia. In order to draw a clear conclusion, studies with larger cohorts are needed to establish this correlation.

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Keywords : Cleft lip, Cleft palate, Leukemia, Children