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Efficacy and safety of neural stem cell therapy for spinal cord injury: A systematic literature review - 22/07/20

Doi : 10.1016/j.therap.2020.06.011 
Santosh Tiwari a, , Shaswati Khan b, Shiva V. Kumar c, Rohit Rajak d, Asma Sultana a, Shaik Abjal Pasha e, Divya Gauba c, Pinaki Ghosh c, Tanu Khurana f, Aishwarya Kulkarni g, Yugandhar P. Reddy h, Aleem A. Khan a, Varun Kumar Sharma a, i, j,
a Real-World Insights Group, Centre for Liver Research and Diagnostics, Deccan College of Medical sciences, 500058 Hyderabad, India 
b Department of Genetics, Osmania University, 500058 Hyderabad, India 
c Poona College of Pharmacy, Bharati Vidyapeeth University, 411038 Pune, India 
d The International Telematica University, 00186 Rome, Italy 
e Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, 11433 Riyadh, Saudi Arabia 
f Lord Shiva College of Pharmacy, 125055 Sirsa, India 
g Bandodkar College of Science Advanced Centre, 400601 Mumbai, India 
h Department of Zoology, Adoni College of Arts and Science, 518302 Adoni, Kurnool, India 
i Department of Biotechnology & Microbiology, School of Sciences, Noida International University, 203201 Gautam Budh Nagar, India 
j Department of Surgery, Oncology and Gastroenterology, University of Padova, 35124 Padova, Italy 

Corresponding author at: Department of Biotechnology and Microbiology, School of Sciences, Noida International University-NIU, Sector-17 A, Yamuna Expressway, Gautam Budh Nagar 201308 Uttar Pradesh, India.Department of Biotechnology and Microbiology, School of Sciences, Noida International University-NIU, Sector-17 A, Yamuna Expressway, Gautam Budh Nagar Uttar Pradesh201308India⁎⁎Co-corresponding author at: Real-World Insights Group, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500058, India.Real-World Insights Group, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, KanchanbaghHyderabad 500058India
Sous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le Wednesday 22 July 2020

Summary

Aims

To summarize the evidence on the efficacy and safety of neural stem cell therapy (NSCT) for the treatment of spinal cord injury (SCI).

Methods

A systematic literature review of Medline®, EMBASE® and Cochrane library was performed to identify studies reporting efficacy and safety of NSCT in SCI. Articles were included if they reported efficacy and safety data of SCI patients who received NSCT.

Results

Overall, four studies of the 277 records met all the study eligibility criteria. Over the 1-year follow-up period, motor scores were significantly higher among patients who received NSCT compared with those who did not (American Spinal Injury Association [ASIA] motor scores (mean±standard deviation [SD]): 7.9±1.2 versus 3.9±0.6; upper extremity motor score: 7.8±2.1 versus 3.9±0.6, both P<0.05). Sensory scores (pinprick score: 4.8±1.3 versus 2.9±0.6; P=0.5; light touch score: 6.9±3.1 versus 2.3±0.5, P=0.3), ASIA impairment scale (26% versus 7%) or pain score (baseline: 2.4±0.6; 1-year: 3.4±0.4) were comparable in both NSCT and non-NSCT cohorts. Over the 1-year follow-up period, the graded redefined assessment of strength, sensibility, and prehension and international standards for neurological classification of SCI scores showed a mean improvement of 14.8 and 17.8 points respectively. Overall, treatment with NSCT showed favorable safety and tolerability profile.

Conclusions

Due to the limited and poor-quality evidence, it is too early to make robust conclusions on the efficacy of NSCT in the treatment of SCI. However, based on the included studies, NSCT seems to be a potential option worth exploring among patients with SCI. Nonetheless, prospective, randomized trials in larger cohorts are needed to validate the efficacy and safety of NSCT in the treatment of SCI.

Le texte complet de cet article est disponible en PDF.

Keywords : ASIA motor scores, Neural stem cell therapy, Safety, Sensory scores, Spinal cord injury


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© 2020  Société française de pharmacologie et de thérapeutique. Publié par Elsevier Masson SAS. Tous droits réservés.
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