Reflectance confocal microscopy terminology glossary for melanocytic skin lesions: A systematic review - 31/07/20

Doi : 10.1016/j.jaad.2020.05.097

Cristian Navarrete-Dechent, MD ^a,^b, Konstantinos Liopyris, MD ^b,^c, Jilliana Monnier, MD ^b, Saud Aleissa, MD ^b, Lindsay M. Boyce, BS ^d, Caterina Longo, MD ^e,^f, Margaret Oliviero, ARNP ^g, Harold Rabinovitz, MD ^g, Ashfaq A. Marghoob, MD ^b, Allan C. Halpern, MD ^b, Giovanni Pellacani, MD ^e, Alon Scope, MD ^b,^h, Manu Jain, MD ^b,^⁎
^a Department of Dermatology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
^b Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
^c Department of Dermatology, University of Athens, Andreas Syggros Hospital of Skin and Venereal Diseases, Athens, Greece
^d Library, Memorial Sloan Kettering Cancer Center, New York, New York
^e Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
^f Azienda Unità Sanitaria Locale–Istituo di Ricovero e Cura a Carattere Scientifico di Reggio Emilia, Centro Oncologico ad Alta Tecnologia Diagnostica-Dermatologia, Reggio Emilia, Italy
^g Dermatology Associates, Plantation, Florida
^h The Kittner Skin Cancer Screening and Research Institute, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

^∗Reprint requests to: Manu Jain, MD, Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 16 E 60th St, New York, NY 10022.Dermatology ServiceDepartment of MedicineMemorial Sloan Kettering Cancer Center16 E 60th StNew YorkNY10022

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Abstract

Background

There is lack of uniformity in the reflectance confocal microscopy (RCM) terminology for melanocytic lesions.

Objective

To review published RCM terms for melanocytic lesions and identify redundant, synonymous terms.

Methods

A systematic review of original research articles adhering to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines was conducted until August 15, 2018. Two investigators gathered all published RCM terms used to describe melanoma and melanocytic nevi. Synonymous terms were grouped based on similarity in definition and in histopathologic correlation.

Results

Out of 156 full-text screened articles, 59 studies met the inclusion criteria. We identified 209 terms; 191 (91.4%) corresponding to high-magnification/cellular-level terms and 18 (8.6%) corresponding to low-magnification/architectural patterns terms. The overall average use frequency of RCM terms was 3.1 times (range, 1-31). By grouping of individual RCM terms based on likely synonymous definitions and by eliminating terms lacking clear definition, the total number of RCM terms could be potentially reduced from 209 to 40 terms (80.8% reduction).

Limitations

Non-English and non–peer-reviewed articles were excluded.

Conclusions

This systematic review of published RCM terms identified significant terminology redundancy. It provides the basis for subsequent terminology consensus on melanocytic neoplasms.

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Key words : diagnosis, melanocytic, melanoma, nevus, noninvasive, reflectance confocal microscopy, systematic review

Abbreviations used : DEJ, NML, RCM

Plan

Methods

Eligibility criteria

Information sources, search, and study selection

Data collection and extraction process

Summary measures and statistical analysis

Results

High-magnification/cellular-level resolution terms

Low-magnification/architectural patterns terms

Discussion

Limitations

Conclusion

	Drs Scope and Jain are cosenior authors.
	Funding sources: Supported in part by a grant from the National Cancer Institute/National Institutes of Health (P30-CA008748) made to the Memorial Sloan-Kettering Cancer Center. Dr Scope's reflectance confocal microscopy research is funded by the Israel Science Foundation (ISF-1546-16).
	Disclosure: Dr Halpern is a paid consultant for Canfield Scientific, Inc., is on the advisory board for SciBase, and was on the advisory board for Caliber ID. Drs Navarrete-Dechent, Liopyris, Monnier, and Aleissa; Authors Boyce and Oliviero; and Drs Rabinovitz, Marghoob, Pellacani, Scope, and Jain have no conflicts of interest to declare.
	IRB approval status: Reviewed and approved by Memorial Sloan Kettering Cancer Center (#17-083).