06-56 - AORTIC ROOT DILATATION AND STIFFNESS IN OBSTRUCTIVE SLEEP APNEA SYNDROME: A PRELIMINARY STUDY - 09/04/08
Meuleman [1],
F Boccara [2],
S Ederhy [2],
S Janower [2],
F Raoux [2],
G Dufaitre [2],
L Boyer-Chatenet [2],
B Fleury [3],
A Cohen [1]
Voir les affiliationsBackground: Obstructive sleep apnea syndrome (OSAS) has been associated with an increased risk of arterial hypertension (AH), coronary artery disease, heart failure, stroke and death. Whether OSAS influences aortic root size has not been fully investigated. The aim of our study was to investigate aortic root diameter and aortic stiffness in OSAS.
Methods: Using transthoracic Doppler echocardiography, we studied 38 OSAS patients (Pts) (mean age 52.3 ± 10 years, 33 men), with no overt cardiovascular disease. AH was documented in 13 patients. The following parameters were off-line measured: aortic diameter at sinuses of valsalva, aortic regurgitation (AR) grade, left ventricular (LV) mass, relative wall thickness (h/R), LV ejection fraction (Simpson rule), systolic pulmonary artery pressure (sPAP). Aortic stiffness was measured with carotid-femoral pulse wave velocity (PWV).
Results: The main results are presented according to aortic diameter tertiles. The mean duration of OSAS was 5.4 ± 4.6 years and 85% of patients had a treatment with continuous positive airway pressure. The mean aortic root diameter was 35.3 mm (26,9-44,6 mm). Thirteen patients (33%) had aortic root diameter > 39 mm (third tertile). Seven patients had grade 1 aortic regurgitation (AR). No Pts had grade > 2 AR. LVM was significantly higher in the highest aortic root diameters.
On multivariate analysis, adjusted on age, pulse pressure, PWV and BMI, AH was not a predictor of aortic root dilatation (p = 0.21), whereas PWV was a significant predictor of aortic root dilatation (beta coefficient – 1.7; p = 0.003).
Conclusions: These preliminary results suggest that aortic root diameter enlargement is associated with OSAS, independently from the presence of arterial hypertension. Further methodological refinements are however necessary to establish the respective role of OSAS and associated factors in the aortic burden.
Plan
© 2007 Elsevier Masson SAS. Tous droits réservés.
Vol 100 - N° 12
P. 1086-1087 - décembre 2007 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.