Activation of the renin-angiotensin-aldosterone system is associated with Acute Kidney Injury in COVID-19 - 19/08/20
Doi : 10.1016/j.accpm.2020.06.006
Emmanuel Dudoignon a, c, 1, Nabila Moreno b, 1, Benjamin Deniau a, e, Maxime Coutrot a, Romain Longer b, Quentin Amiot b, Alexandre Mebazaa a, c, Romain Pirracchio d, François Depret a, c, Matthieu Legrand a, c, d, 1, ⁎ 
a Assistance Publique–Hôpitaux de Paris (AP–HP), Groupe Hospitalier St Louis-Lariboisière, Department of Anaesthesiology and Critical Care and Burn Unit, Paris, France
b Assistance Publique–Hôpitaux de Paris (AP–HP), Groupe Hospitalier St Louis-Lariboisière, Department of Biochemistry, Paris, France
c University of Paris, Paris, France
d Department of Anesthesiology and Peri-operative Medicine and Critical Care Medicine, University of California, San Francisco, California
e Inserm UMR-S 942, Mascot, Lariboisière Hospital, Paris, France
⁎Corresponding author at: University of California San Francisco Memory and Aging Center, Department of Anesthesiology and Peri-operative Care, 500, Parnassus Avenue, San Francisco, United States.University of California San Francisco Memory and Aging Center, Department of Anaesthesiology and Peri-operative Care500, Parnassus AvenueSan FranciscoUnited States
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Abstract |
The pathophysiology of acute kidney injury (AKI) in COVID-19 patients is still poorly understood. SARS-CoV-2 has been suggested to modulate the renin-angiotensin-aldosterone system (RAAS). In this series of COVID-19 critically ill patients, we report evidence of activation of the RAAS in COVID-19 patients with AKI.
Le texte complet de cet article est disponible en PDF.Keywords : Renin-angiotensin-aldosterone system, COVID-19
Plan
© 2020
Société française d'anesthésie et de réanimation (Sfar). Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 39 - N° 4
P. 453-455 - août 2020 Retour au numéro
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