Number needed to biopsy ratio and diagnostic accuracy for melanoma detection - 19/08/20
Abstract |
Background |
The number needed to biopsy (NNB) ratio for melanoma diagnosis is calculated by dividing the total number of biopsies by the number of biopsied melanomas. It is the inverse of positive predictive value (PPV), which is calculated by dividing the number of biopsied melanomas by the total number of biopsies. NNB is increasingly used as a metric to compare the diagnostic accuracy of health care practitioners.
Objective |
To investigate the association of NNB with the standard statistical measures of sensitivity and specificity.
Methods |
We extracted published diagnostic accuracy data from 5 cross-sectional skin cancer reader studies (median [min-max] readers/study was 29 [8-511]). Because NNB is a ratio, we converted it to PPV.
Results |
Four studies showed no association and 1 showed a negative association between PPV and sensitivity. All 5 studies showed a positive association between PPV and specificity.
Limitations |
Reader study data.
Conclusions |
An individual health care practitioner with a lower NNB is likely to have a higher specificity than one with a higher NNB, assuming they practice under similar conditions; no conclusions can be made about their relative sensitivities. We advocate for additional research to define quality metrics for melanoma detection and caution when interpreting NNB.
Le texte complet de cet article est disponible en PDF.Key words : diagnostic accuracy, melanoma, melanoma positive predictive value, melanoma screening, melanoma sensitivity, melanoma specificity, NNB, number needed to biopsy
Abbreviations used : HCP, NNB, PPV
Plan
Funding sources: Supported in part by a grant from the National Cancer Institute/National Institutes of Health (P30-CA008748). |
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Conflicts of interest: None disclosed. |
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IRB approval status: Reviewed and approved by Memorial Sloan Kettering Cancer Center (#16-974). |
Vol 83 - N° 3
P. 780-787 - septembre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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