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Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming - 28/08/20

Doi : 10.1016/j.biopha.2020.110281 
Jian Chen a, b, 1, Yong-kui Wang c, 1, Yuan Gao d, Ling-San Hu e, Jiang-wei Yang f, Jian-ru Wang g, Wen-jie Sun h, Zhi-qiang Liang a, , Ye-min Cao a, b, , Yong-bing Cao a, b,
a Shanghai TCM-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China 
b Institute of Vascular Anomalies, Shanghai Academy of Traditional Chinese Medicine, Shanghai, 200082, China 
c The Department of Orthopaedics, the first affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China 
d Traditional Chinese Recovery and Treatment Center, Zhejiang Rehabilitation Medical Center, Hangzhou 310053, China 
e Bao an Hospital of Traditional Chinese Medicine, Shenzhen 518133, China 
f Mental Health Center, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China 
g The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000 China 
h Department of general surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China 

Corresponding authors at: Shanghai TCM‐Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China.Shanghai TCM‐Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai200082China

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Highlights

A novel FUNP analysis on QFPD function.
QFPD act on COVID-19 via anti-viral, anti-inflammatory and metabolic programming.
9 QFPD ingredients presented good molecular docking score for 2019-nCov.
SGMH, MXSG and Others are the top 3 efficient formula for COVID-19.

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Abstract

Qingfei Paidu decoction (QFPD), a multi-component herbal formula, has been widely used to treat COVID-19 in China. However, its active compounds and mechanisms of action are still unknown. Firstly, we divided QFPD into five functional units (FUs) according to the compatibility theory of traditional Chinese medicine. The corresponding common targets of the five FUs were all significantly enriched in Go Ontology (oxidoreductase activity, lipid metabolic process, homeostatic process, etc.), KEGG pathways (steroid biosynthesis, PPAR signaling pathway, adipocytokine signaling pathway, etc.), TTD diseases (chronic inflammatory diseases, asthma, chronic obstructive pulmonary Disease, etc.), miRNA (MIR183), kinase (CDK7) and TF (LXR). QFPD contained 257 specific targets in addition to HCoV, pneumonia and ACE2 co-expression proteins. Then, network topology analysis of the five components-target-pathway-disease networks yielded 67 active ingredients. In addition, ADMET estimations showed that 20 compounds passed the stringent lead-like criteria and in silico drug-likeness test with high gastrointestinal absorption and the median lethal dose (LD50 > 1600 mg/kg). Moreover, 4 specific ingredients (M3, S1, X2 and O2) and 5 common ingredients (MS1, MX16, SX1, WO1 and XO1) of QFPD presented good molecular docking score for 2019-nCov structure and non-structure proteins. Finally, drug perturbation of COVID-19 network robustness showed that all five FUs may protect COVID-19 independently, and target 8 specifically expressed drug-attacked nodes which were related to the bacterial and viral responses, immune system, signaling transduction, etc. In conclusion, our new FUNP analysis showed that QFPD had a protection effect on COVID-19 by regulating a complex molecular network with safety and efficacy. Part of the mechanism was associated with the regulation of anti-viral, anti-inflammatory activity and metabolic programming.

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Abbreviations : FUNP, MSXG, SGMH, XCH, WLS, BXTM, YDBF, ADMET

Keywords : Qingfei paidu decoction, COVID-19, Functional units of network pharmacology, Anti-viral, Anti-inflammatory, Metabolic programming


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Vol 129

Article 110281- septembre 2020 Retour au numéro
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