Relations between genetic background and intracardiac scars characteristics in patients with arrhythmogenic right ventricular cardiomyopathy - 25/09/20
Résumé |
Introduction |
Relations between scars characteristics and genetic background in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) has not been investigated so far.
Objective |
To investigate if genetic background change the scars characteristics in ARVC.
Method |
66 patients with ARVC (24 with culprit mutation) having undergone endocardial mapping have been retrospectively included. Every patient had a diagnosis of ARVC according to the task force criteria. Localisations, surfaces and perimeters of low votage areas (<1.5mV in bipolar and<5.5mV in unipolar) have been correlated to the existence of a culprit mutation, as well as volumes and ejection fraction of both ventricles by echocardiography, MRI or radionuclide.
Results |
Mutated patients more often had altered right ventricular ejection fraction (<0.05) and left ventricular late gadolinium enhancement (P=0.01). Right ventricle was more dilated (P=0.03), with larger scars in bi and unipolar voltage maps (P<0.05). Localisation of scars was linked to the genetic background, with more infero-lateral (P=0.01) or multiple scars (P=0.01) in mutated patients, while prevalence of outflow tract or apical scars did not differ.
Conclusion |
In our ARVC population, culprit mutations increase size and number of intracardiac scars and degree of biventricular involvment, and localize scars in infero-lateral areas compared to patients without mutation.
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Vol 12 - N° 2-4
P. 263-264 - octobre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.