Platelet-rich plasma (PRP) shows promise as an androgenetic alopecia (AGA) treatment.
To conduct a randomized placebo-controlled split-scalp study to investigate the effects of PRP on hair regrowth and thickness.
Two 7.6-cm × 7.6-cm squares were tattooed on the scalps of 35 study participants with AGA. Areas were randomly assigned to intradermal injection with PRP or saline. Participants received 3 monthly treatment sessions with evaluation 3 months after the final treatment.
Hair density in the PRP-treated area was significantly increased compared with baseline at all visits. At the final assessment, hair density in PRP-treated areas increased from 151 ± 39.82 hairs/cm2 at baseline to 170.96 ± 37.14 hairs/cm2, a mean increase of approximately 20 hairs/cm2 (P < .05). However, hair density in placebo-treated areas also increased from 151.04 ± 41.99 hairs/cm2 to 166.72 ± 37.13 hairs/cm2 (P < .05). There was no significant difference in hair density change between the 2 groups (P > .05). No serious adverse events were reported.
Possible PRP diffusion due to split-scalp study design as well as microinjections causing microinjury to both sides.
PRP may have benefit in increasing hair density.Le texte complet de cet article est disponible en PDF.
Key words : androgenetic alopecia, female pattern hair loss, hair, male pattern hair loss, platelet-rich plasma, randomized controlled trial
Abbreviations used : AGA, PRP
| Funding sources: This study was funded by Regen Lab SA (Le Mont-sur-Lausanne, Switzerland).
| Conflicts of interest: Dr Shapiro is a consultant for Aclaris Therapeutics, Incyte, and Replicel Life Sciences and is principal investigator for Regen Lab. Dr Lo Sicco is a coinvestigator for Regen Lab. Authors Ho, Sukhdeo, and Yin have no conflicts of interest to declare.
| IRB approval status: The New York University Grossman School of Medicine Institutional Review Board reviewed and approved this study.
| Reprints not available from the authors.