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Evaluation of platelet-rich plasma as a treatment for androgenetic alopecia: A randomized controlled trial - 10/10/20

Doi : 10.1016/j.jaad.2020.07.006 
Jerry Shapiro, MD a, , Anthony Ho, MD a, Kumar Sukhdeo, MD, PhD b, Lu Yin, BA a, Kristen Lo Sicco, MD a
a Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York 
b Pilaris Dermatology, New York, New York 

Correspondence to: Jerry Shapiro, MD, Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, 530 1st Ave, #7R, New York, NY 10016.Ronald O. Perelman Department of DermatologyNew York University Grossman School of Medicine530 1st Ave, #7RNew YorkNY10016

Abstract

Background

Platelet-rich plasma (PRP) shows promise as an androgenetic alopecia (AGA) treatment.

Objective

To conduct a randomized placebo-controlled split-scalp study to investigate the effects of PRP on hair regrowth and thickness.

Methods

Two 7.6-cm × 7.6-cm squares were tattooed on the scalps of 35 study participants with AGA. Areas were randomly assigned to intradermal injection with PRP or saline. Participants received 3 monthly treatment sessions with evaluation 3 months after the final treatment.

Results

Hair density in the PRP-treated area was significantly increased compared with baseline at all visits. At the final assessment, hair density in PRP-treated areas increased from 151 ± 39.82 hairs/cm2 at baseline to 170.96 ± 37.14 hairs/cm2, a mean increase of approximately 20 hairs/cm2 (P < .05). However, hair density in placebo-treated areas also increased from 151.04 ± 41.99 hairs/cm2 to 166.72 ± 37.13 hairs/cm2 (P < .05). There was no significant difference in hair density change between the 2 groups (P > .05). No serious adverse events were reported.

Limitations

Possible PRP diffusion due to split-scalp study design as well as microinjections causing microinjury to both sides.

Conclusion

PRP may have benefit in increasing hair density.

Le texte complet de cet article est disponible en PDF.

Key words : androgenetic alopecia, female pattern hair loss, hair, male pattern hair loss, platelet-rich plasma, randomized controlled trial

Abbreviations used : AGA, PRP


Plan


 Funding sources: This study was funded by Regen Lab SA (Le Mont-sur-Lausanne, Switzerland).
 Conflicts of interest: Dr Shapiro is a consultant for Aclaris Therapeutics, Incyte, and Replicel Life Sciences and is principal investigator for Regen Lab. Dr Lo Sicco is a coinvestigator for Regen Lab. Authors Ho, Sukhdeo, and Yin have no conflicts of interest to declare.
 IRB approval status: The New York University Grossman School of Medicine Institutional Review Board reviewed and approved this study.
 Reprints not available from the authors.


© 2020  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 83 - N° 5

P. 1298-1303 - novembre 2020 Retour au numéro
Article précédent Article précédent
  • The effect of platelet-rich plasma on female androgenetic alopecia: A randomized controlled trial
  • Danielle P. Dubin, Matthew J. Lin, Hayley M. Leight, Aaron S. Farberg, Richard L. Torbeck, William B. Burton, Hooman Khorasani
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