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New-onset depression among children, adolescents, and adults with hidradenitis suppurativa - 10/10/20

Doi : 10.1016/j.jaad.2020.05.090 
Shari Wright, BS, Andrew Strunk, MA, Amit Garg, MD
 Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York 

Correspondence to: Amit Garg, MD, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 1991 Marcus Ave, Suite 300, New Hyde Park, NY, 11042.Donald and Barbara Zucker School of Medicine at Hofstra/Northwell1991 Marcus Ave, Suite 300New Hyde ParkNY11042

Abstract

Background

Information on the risk of depression among children, adolescents, and adults with hidradenitis suppurativa (HS) is limited.

Objective

To compare the risk of new-onset depression in patients with HS with that of control individuals.

Methods

Retrospective cohort analysis of 49,280 adult and 3042 pediatric patients with HS and matched control individuals identified by using electronic health record data. The primary outcome was incident depression.

Results

The crude incidence rate was 4.8 per 100 person-years in adult patients with HS compared to 3.0 per 100 person-years in control individuals. Among pediatric patients, the crude incidence rate was 4.2 per 100 person-years in patients with HS compared with 2.3 per 100 person-years in control individuals. In adjusted analysis, adults and pediatric patients with HS had a 10% (hazard ratio, 1.10; 95% confidence interval, 1.07-1.13; P < .001) and 26% (hazard ratio, 1.26; 95% confidence interval, 1.10-1.44; P < .001), respectively, increased risk of developing depression compared to control individuals. Among patients with HS, factors associated with depression included female sex, white race, smoking, and body mass index/obesity in adults and pediatric patients and substance abuse in adults only.

Limitations

Patients not seeking care in health systems within the database were not captured.

Conclusion

Children, adolescents, and adults with HS are at an increased risk for developing depression, independent of other common risk factors for depression.

Le texte complet de cet article est disponible en PDF.

Key words : comorbidity, depression, Explorys, hidradenitis suppurativa, incidence, mood disorder, new-onset

Abbreviations used : BMI, CI, HR, HS, ICD


Plan


 Funding sources: Supported in part by an education grant from AbbVie. AbbVie had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
 Disclosure: Dr Garg has served as an advisor for AbbVie, Amgen, Boehringer Ingelheim, Janssen, Pfizer, Incyte, Viela Bio, and UCB and has received honoraria. Authors Wright and Strunk have no conflicts of interest to declare.
 IRB approval status: Reviewed and approved by the human subjects committee at the Feinstein Institutes for Medical Research at Northwell Health.
 Reprints not available from the authors.


© 2020  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 83 - N° 5

P. 1360-1366 - novembre 2020 Retour au numéro
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