Médecine

Paramédical

Autres domaines


S'abonner

Long-term effectiveness and safety of treatment with dupilumab in patients with atopic dermatitis: Results of the TREAT NL (TREatment of ATopic eczema, the Netherlands) registry - 10/10/20

Doi : 10.1016/j.jaad.2020.05.128 
Angela L. Bosma, MD a, , Linde E.M. de Wijs, MD b, Michel H. Hof, PhD c, Beau R. van Nieuwenhuizen, MD a, Louise A.A. Gerbens, MD, PhD a, Maritza A. Middelkamp-Hup, MD, PhD a, DirkJan Hijnen, MD, PhD b, Phyllis I. Spuls, MD, PhD a
a Department of Dermatology, Amsterdam Public Health, Immunity and Infections, Amsterdam University Medical Centers, location AMC, University of Amsterdam, Amsterdam, the Netherlands 
b Department of Dermatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands 
c Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers, location AMC, University of Amsterdam, Amsterdam, the Netherlands 

Correspondence and reprint requests to: A.L. (Angela) Bosma, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.Meibergdreef 9AmsterdamAZ1105the Netherlands

Abstract

Background

Evidence on long-term dupilumab treatment for atopic dermatitis in daily practice is lacking.

Objective

To investigate patient characteristics, treatment aspects, effectiveness, and safety of up to 84 weeks of dupilumab treatment.

Methods

An observational prospective cohort study was conducted of patients with atopic dermatitis starting dupilumab in routine clinical care.

Results

Of the 221 included patients, 103 used systemic therapy at baseline. At 84 weeks, we found a change of −15.2 (SE, 1.7) for the Eczema Area and Severity Index, −16.9 (SE, 1.4) for the Patient-Oriented Eczema Measure, and −17.2 (SE, 1.6) for the Dermatology Life Quality Index. We found a trend for improvement over time for the Investigator Global Assessment and Numerical Rating Scale for pruritus. Severe (n = 79) including serious (n = 11) adverse events were observed in 69 patients. Eye complaints were most frequently reported (n = 46). Twenty-one patients adjusted the regular dosing schedule, and 14 patients discontinued treatment, mainly due to ineffectiveness (n = 7).

Limitations

Only adverse events of severe and serious nature were registered for feasibility reasons.

Conclusion

Daily practice dupilumab treatment of up to 84 weeks is generally well-tolerated, apart from the reporting of eye complaints. It can be considered a long-term effective treatment for atopic dermatitis in combination with topical and initial concomitant systemic treatment, showing a sustained improvement of signs, symptoms, and quality of life.

Le texte complet de cet article est disponible en PDF.

Key words : atopic dermatitis, atopic eczema, daily practice, dupilumab, effectiveness, registry, routine clinical care, safety, systemic immunomodulating treatment

Abbreviations used : AD, AE, DLQI, EASI, EMC, IGA, NRS, POEM, TREAT NL, UMC


Plan


 Funding sources: This study was partly funded by a government grant through ZonMw (The Netherlands Organization for Health Research and Development), program Rational Pharmacotherapy.
 Conflicts of interest: Dr Middelkamp-Hup is a consultant for Sanofi and Pfizer. Dr Hijnen is an investigator for LEO Pharma, MedImmune/AstraZeneca, Novartis, and Sanofi/Regeneron and is a consultant for Regeneron/Sanofi, LEO Pharma, MedImmune/AstraZeneca, Novartis, Incyte, Janssen, and Pfizer. Dr Spuls has been a consultant in the past for Sanofi 111017 and AbbVie 041217 (unpaid), received independent research grants >5 years ago, and is involved in performing clinical trials with many pharmaceutical industries that manufacture drugs used for the treatment of psoriasis and atopic dermatitis for which financial compensation is paid to the hospital. Drs Bosma, de Wijs, van Nieuwenhuizen, and Gerbens have no conflicts of interest to declare.
 IRB approval status: Our study was exempted from evaluation by the local Medical Research Ethics Committees (MEC-2017-1123; W18_097#18.123).


© 2020  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
Ajouter à ma bibliothèque Retirer de ma bibliothèque Imprimer
Export

    Export citations

  • Fichier

  • Contenu

Vol 83 - N° 5

P. 1375-1384 - novembre 2020 Retour au numéro
Article précédent Article précédent
  • Bimekizumab for patients with moderate to severe plaque psoriasis: 60-week results from BE ABLE 2, a randomized, double-blinded, placebo-controlled, phase 2b extension study
  • Andrew Blauvelt, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb, Nancy Cross, Cynthia Madden, Maggie Wang, Christopher Cioffi, Christopher E.M. Griffiths
| Article suivant Article suivant
  • Bidirectional relationship between atopic dermatitis and inflammatory bowel disease: A systematic review and meta-analysis
  • Hanjae Lee, Ji Hoo Lee, Seong-Joon Koh, Hyunsun Park

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

Mon compte


Plateformes Elsevier Masson

Déclaration CNIL

EM-CONSULTE.COM est déclaré à la CNIL, déclaration n° 1286925.

En application de la loi nº78-17 du 6 janvier 1978 relative à l'informatique, aux fichiers et aux libertés, vous disposez des droits d'opposition (art.26 de la loi), d'accès (art.34 à 38 de la loi), et de rectification (art.36 de la loi) des données vous concernant. Ainsi, vous pouvez exiger que soient rectifiées, complétées, clarifiées, mises à jour ou effacées les informations vous concernant qui sont inexactes, incomplètes, équivoques, périmées ou dont la collecte ou l'utilisation ou la conservation est interdite.
Les informations personnelles concernant les visiteurs de notre site, y compris leur identité, sont confidentielles.
Le responsable du site s'engage sur l'honneur à respecter les conditions légales de confidentialité applicables en France et à ne pas divulguer ces informations à des tiers.