Conflicting evidence exists on the effect of NSAIDs on BE risk.
The results indicated that use of NSAIDs was associated with a reduced risk of BE.
The results indicated that there was a sex-dependent difference regarding the effect of NSAIDs on BE risk.
Conflicting evidence exists regarding the effect of NSAIDs on the risk of Barrett’s esophagus. The purpose of this study is to systematically assess this effect through a meta-analysis.
Accordingly, clinical studies on NSAID use and Barrett’s esophagus risk were searched on PubMed, Embase, and the Cochrane Library. Following this, meta-analyses were conducted using the RevMan 5.3 software. The pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were used as the effect size.
Seven eligible studies (one cohort study and six case-control studies) were included for the present meta-analysis by adopting a fixed-effect model, which demonstrated that NSAIDs could reduce Barrett’s esophagus risk (OR: 0.84, 95%CI:0.75−0.94, P＜0.05). Moreover, subgroup analyses done according to sex showed that NSAIDs could reduce Barrett’s esophagus risk in females (OR 0.85; 95% CI 0.73–0.99; P = 0.04), without heterogeneity between studies (P = 1.00 and I2 = 0%). However, this relationship was not evident in males (OR 0.85; 95% CI 0.68–1.07; P = 0.16).
Overall, this meta-analysis provided high quality evidence that use of NSAIDs is associated with a reduced risk of Barrett’s esophagus. However, the presence of a sex-dependent difference remains to be clarified.Le texte complet de cet article est disponible en PDF.
Keywords : NSAIDs, Barrett’s esophagus, Meta-analysis