Guanxinshutong capsule ameliorates cardiac function and architecture following myocardial injury by modulating ventricular remodeling in rats - 27/10/20
pages | 15 |
Iconographies | 14 |
Vidéos | 0 |
Autres | 0 |
Graphical abstract |
Highlights |
• | The role of Guanxinshutong capsule in myocardial injury is investigated. |
• | Myocardial injury-transverse aortic constriction causes ventricular remodeling. |
• | Guanxinshutong capsule ameliorates cardiac hypertrophy and fibrosis in rats. |
• | This study provides a guidance for the treatment of myocardial injury in clinic. |
Abstract |
Guanxinshutong capsule (GXST), which consists of five traditional Chinese medicines, has been used for a long time in China for the treatment of cardiovascular diseases, such as coronary artery disease and myocardial infarction. However, the effects on GXST on myocardial injury (MI) have not been studied in detail. In these experiments, we found that GXST administration decreased MI-associated ventricular remodeling (VR) with a reduction in interventricular septal thickness in diastole (IVSd), left ventricular posterior wall diameter in systole (LVPWs), and left ventricular posterior wall diameter in diastole (LVPWd) to ameliorate cardiac function and architecture, as measured by echocardiography. Furthermore, histological analysis showed that GXST could ameliorate pathological alterations in the myocardium. And Sirius red staining, wheat germ agglutinin staining and inflammation-related immunohistochemistry results showed that GXST ameliorated the fibrosis areas, cardiac hypertrophy and inflammation (IL-6 and TNF-α). In addition, GXST upregulated intercellular junction proteins (N-cad and Cx-43) and downregulated the angiogenesis-related proteins (PDGF and VEGFA), myocardial fibrosis-related proteins (TGF-β1), and matrix metalloproteinase (MMP-2 and MMP-9). We also found that GXST medium-dose group (1 g/kg/d) dosage was the most efficacious. In conclusion, GXST protected cardiac tissues against MI by reducing VR, thus indicating the potential application of GXST in the treatment of MI.
Le texte complet de cet article est disponible en PDF.Abbreviations : HPLC, GXST, SD, MI, VR, TAC, HE, Control, Model, GXST-LD, GXST-MD, GXST-HD, IVSd, LVPWs, LVPWd, WGA, IL-6, TNF-α, N-cad, Cx-43, PDGF, TGF-β1, VEGFA, MMP-2, MMP-9, ELISA, WHO
Keywords : Guanxinshutong capsule, Myocardial injury, Ventricular remodeling, Intercellular junction, Angiogenesis, Myocardial fibrosis
Plan
Vol 130
Article 110527- octobre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?