NF-?B inhibitors in treatment and prevention of lung cancer - 27/10/20
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Graphical abstract |
Highlights |
• | NF-κB signaling is involved in the progression and spread of lung tumorigenesis. |
• | NF-κB is a pleiotropic transcription factor that influence oncogenesis. |
• | Development of NF-κB pathway antagonists has vital role in prevention of lung cancer progression. |
Abstract |
Intracellular signalling pathways have provided excellent resource for drug development particularly in the development of cancer therapeutics. A wide variety of malignancies common in human exhibit aberrant NF-κB constitutive expression which results in tumorigenic processes and cancer survival in a variety of solid tumour, including pancreatic cancer, lung, cervical, prostate, breast and gastric carcinoma. Numerous evidences indicate that NF-κB signalling mechanism is mainly involved in the progression of several cancers which may intensify an enhanced knowledge on its role in disease particularly lung tumorigenesis. This has led to tremendous research in designing a variety of NF-κB antagonists with enhanced clinical applications through different approaches the most common being suppression of IκB kinase (IKK) beta activity. Many NF-κB inhibitors for lung cancer are now under clinical trials. Preliminary results of clinical trials for several of these agents include small-molecule inhibitors and monoclonal antibodies. A few combinatorial treatment therapies are currently under investigation in the clinics and have shown promise, particularly NF-κB inhibition associated with lung cancer.
Le texte complet de cet article est disponible en PDF.Keywords : NF-κB, Antagonists, Signalling pathways, Drug development, Lung tumorigenesis
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Vol 130
Article 110569- octobre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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