Competitive endogenous network of lncRNA, miRNA, and mRNA in the chemoresistance of gastrointestinal tract adenocarcinomas - 27/10/20
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Iconographies | 6 |
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Graphical abstract |
Highlights |
• | The lncRNA-miRNA-mRNA ceRNA network can regulate the chemoresistance in GTAs. |
• | The dynamic factors affecting MREs regulate the ceRNA network and chemoresistance. |
• | Components of TME including CAF, EV, hypoxia and ECM are involved. |
• | ceRNA networks in the response to chemotherapy in CRC, GC and ESCC are reviewed. |
Abstract |
Chemotherapy is one of the main therapeutic strategies used for gastrointestinal tract adenocarcinomas (GTAs), but resistance to anticancer drugs is a substantial obstacle in successful chemotherapy. Accumulating evidence shows that non-coding RNAs, especially long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), can affect the drug resistance of tumor cells by forming a ceRNA regulatory network with mRNAs. The efficiency of the competing endogenous RNAs (ceRNAs) network can be affected by the number and integrality of miRNA recognition elements (MREs). Dynamic factors such as RNA editing, alternative splicing, single nucleotide polymorphism (SNP), RNA-binding proteins and RNA secondary structure can influence the MRE activity, which may in turn be involved in the regulation of chemoresistance-associated ceRNA network by prospective approaches. Besides activities in a single tumor cell, the components of the tumor micoenvironment (TME) also affect the ceRNA network by regulating the expression of non-coding RNA directly or indirectly. The alternation of the ceRNA network often has an impact on the malignant phenotype of tumor including chemoresistance. In this review, we focused on how MRE-associated dynamic factors and components of TME affected the ceRNA network and speculated the potential association of ceRNA network with chemoresistance. We also summarized the ceRNA network of lncRNAs, miRNAs, and mRNAs which efficiently triggers chemoresistance in the specific types of GTAs and analyzed the role of each RNA as a “promoter” or “suppressor” of chemoresistance.
Le texte complet de cet article est disponible en PDF.Abbreviations : GTA, CRC, ESCC, ncRNA, lncRNA, miRNA, mRNA, ceRNA, TUG1, TYMS, SOX, CASC15, ABCC1, ABC, PCAT-1, CDDP, ZEB1, EMT, miRISC, MREs, 3'UTR, SNP, ADAR, TME, CAF, TGF-β, SDPR, GRM, UBC, VEGF, bFGF, VEGFR1, HIF-1α, TEC, HA, ECM, LDHA, PAI1, IAP, MTX, RBPs, Bcl-2, SIRT1, DOX, GALNT3, MUC1, MEF2, MEF2D, MALAT1, ATG5, TUSC7, DESC1
Keywords : chemoresistance, gastrointestinal tract adenocarcinoma, competing endogenous RNA, miRNA recognition element, lncRNA
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