Molecular hydrogen: A potential radioprotective agent - 27/10/20

Doi : 10.1016/j.biopha.2020.110589

Qiongge Hu ^a,^{^{1
These authors contributed equally to this work.}}, Yunxiang Zhou ^b,^{^{1
These authors contributed equally to this work.}}, Shijie Wu ^c, Wei Wu ^d, Yongchuan Deng ^b, Anwen Shao ^e,⁎
^a Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
^b Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
^c Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
^d Department of Medical Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China
^e Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

^⁎Corresponding author.

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Highlights

•	Summary the underlying mechanism of ionizing radiation and possible choices of radioprotectant.
•	Hydrogen works as a scavenger of free radicals, exert anti-inﬂammation, and anti-apoptosis effect.
•	Hydrogen works as a signal modulator or through regulating gene expression.
•	Summary the main delivery methods of hydrogen.

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Abstract

In recent years, many studies have shown that hydrogen has therapeutic and preventive effects on various diseases. Its selective antioxidant properties were well noticed. Most of the ionizing radiation-induced damage is caused by hydroxyl radicals (OH) from radiolysis of . Since hydrogen can mitigate such damage through multiple mechanisms, it presents noteworthy potential as a novel radio-protective agent. This review analyses possible mechanisms for hydrogen’s radioprotective properties and effective delivery methods. We also look into details of vitro and vivo studies for hydrogen’s radioprotective effects, and clinical practices. We conclude that hydrogen has good potential in radio-protection, with evidence that warrants greater research efforts in this field.