Dysregulation of non-coding RNAs in Rheumatoid arthritis - 27/10/20

Doi : 10.1016/j.biopha.2020.110617

Mohammad Taheri ^a, Reyhane Eghtedarian ^b, Marcel E. Dinger ^c,⁎ , Soudeh Ghafouri-Fard ^b,⁎
^a Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
^b Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
^c School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia

^⁎Corresponding authors.

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Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that is associated with both genetic and environmental factors. Dysregulation of the immune response is the main underlying cause of RA. Based on the growing appreciation of roles of non-coding RNAs in the regulation of the immune response, these transcripts are putative contributors in the pathogenesis of RA. Numerous studies have reported aberrant expression of long non-coding RNAs (lncRNAs) in fibroblast-like synoviocytes or peripheral blood cells of patients with RA. MicroRNAs (miRNAs) are another subset of non-coding RNAs that also have a demonstrated involvement in the pathophysiology of RA. Here we review and summarize data regarding the role of lncRNAs, miRNAs and circular RNAs in the pathogenesis of RA and their potential role as biomarkers and therapeutic targets.

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Keywords : lncRNA, miRNA, circRNA, Biomarker, Rheumatoid arthritis