Melaleuca alternifolia (tea tree) oil and its monoterpene constituents in treating protozoan and helminthic infections - 27/10/20
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| pages | 13 |
| Iconographies | 3 |
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Graphical abstract |
Highlights |
• | Australian tea tree oil display a range of biological and pharmacological properties. |
• | Tea tree oil and its 15 major constituents have effects on parasitic infections. |
• | The parasites include protozoa, nematodes, cestodes, and monogenean parasites. |
• | Prolonged survival or curative effect on protozoan infections in treated animals. |
• | Helminthic burden was reduced or controlled in treated animals. |
Abstract |
Australian tea tree (Melaleuca alternifolia) oil (TTO) and its monoterpene constituents such as terpinen-4-ol (T4O), 1,8-cineole, limonene, p-cymene, and α-terpinene have been shown to be effective in controlling a wide range of parasitic infections. The anti-parasitic effects of these compounds are mainly due to their anti-histamine and anti-acetylcholinesterase activities as well as their ability to modulate host inflammatory responses. This review attempts to summarize recent advances in the uses of TTO and its 15 major monoterpene constituents in treating parasitic infections in both humans and animals. Activities against parasitic protozoans (Plasmodium falciparum, Leishmania spp., Trypanosoma spp., Acanthamoeba castellanii, Trichomonas vaginalis, Eimeria, and Ichthyophthirius multifiliis), nematodes (Haemonchus contortus and Anisakis simplex), cestode (Echinococcus ortleppi), and monogeneans (Gasterosteus spp. and Dactylogyrus minutus) have been reported, showing good potentials in treating parasitic infections. Further studies are necessary for developing anti-parasite therapies using TTO or its monoterpenes constituents.
Le texte complet de cet article est disponible en PDF.Chemical compounds studied in this article : Tea tree oil (TTO), Terpinen-4-ol (T4O), γ-Terpinene, α-Terpinene, 1,8-Cineole, p-Cymene, Terpinolene, α-Terpineol, α-Pinene, Sabinene, Aromadendrene, Ledene, δ-Cadinene, Limonene, Globulol, Viridiflorol
Keywords : Melaleuca alternifolia, Tea tree oil, Protozoa, Nematodes, Cestode, Monogenean parasites
Plan
Vol 130
Article 110624- octobre 2020 Retour au numéro
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