The role of prokineticins in recurrent implantation failure - 30/10/20
, Gorkem Tuncay a, Onur Uysal b, Tuğba Semerci Sevimli b, Nurhan Sahin c, Umran Karabulut a, Ayla Eker Sariboyaci bBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 6 |
| Iconographies | 2 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
The aim of the present study was to investigate the expression patterns of prokineticins (PROK) and prokineticin receptors (PROKR) in the endometrium of women with recurrent implantation failure (RIF). Fifteen (15) women with RIF and 15 fertile controls were enrolled in this study. Endometrial samples were taken from study participants with an endometrial biopsy cannula during the implantation window. Real time polymerase chain reaction and immunohistochemistry were used to determine PROK/PROKR mRNA expression and protein localization, respectively. PROK1 mRNA levels were 6.09 times higher compared to endometrial samples obtained from women with RIF than in samples obtained from fertile controls, whereas PROKR1 mRNA levels were 2.46 times lower in endometrial samples obtained from women with RIF than in samples from fertile controls. In addition, decreased PROKR1 was supported by immunohistochemistry analysis at protein level. There was no statistically significant difference between women with RIF and fertile controls regarding PROK2 and PROKR2 levels. Altered expression of the PROK1/PROKR1 system could be one of the numerous abnormalities in the endometrium of women with RIF.
Le texte complet de cet article est disponible en PDF.Keywords : Endometrium, In vitro fertilization, Prokineticin, Recurrent implantation failure
Plan
Vol 49 - N° 9
Article 101835- novembre 2020 Retour au numéro
Article précédent
- The Role of Analysis of NK Cell Subsets in Peripheral Blood and Uterine Lavage Samples in Evaluation of Patients with Recurrent Implantation Failure
- Yusuf Aytac Tohma, Ugur Musabak, Emre Gunakan, Huseyin Akilli, Gogsen Onalan, Hulusi Bulent Zeyneloglu
- Responses to authors: Vulvar intraepithelial neoplasia: Classification, epidemiology, diagnosis and management
- Mathilde Lebreton, Isis Carton, Susie Brousse, Jean Levêque
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?