Ibrutinib, a Bruton's tyrosine kinase inhibitor, a new risk factor for cryptococcosis - 07/11/20
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Highlights |
• | Cryptococcus neoformans infections are increasingly reported in patients receiving ibrutinib. |
• | Study of 19 cases and analysis from the international pharmacovigilance database. |
• | Cryptococcosis mostly occurred during the first six months and especially the first two months of treatment. |
• | Clinical presentation is often pulmonary. |
• | The outcome is usually favorable despite ibrutinib continuation. |
Abstract |
Purpose |
Invasive fungal diseases and especially Cryptococcus neoformans infections are increasingly reported in patients with hematological malignancies receiving ibrutinib, a Bruton's tyrosine kinase inhibitor.
Patients and method |
We reported three additional cases and reviewed 16 previous published cases together with cases from the international pharmacovigilance database.
Results |
Patients were mainly treated for chronic lymphocytic leukemia. Cryptococcosis mostly occurred during the first six months (66%) and especially the first two months (44%) of treatment. Clinical presentation is often pulmonary (68%) and the outcome is usually favorable despite ibrutinib continuation.
Conclusion |
Clinicians must be aware of this infection in patients with hematological malignancies on ibrutinib.
Le texte complet de cet article est disponible en PDF.Keywords : Chronic lymphocytic leukemia, Cryptococcosis, Ibrutinib
Plan
Vol 50 - N° 8
P. 742-745 - novembre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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