Long non-coding RNA BLACAT1, a novel promising biomarker and regulator of human cancers - 18/11/20
, Shutian Zhang ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Graphical abstract |
Highlights |
• | Upregulated BLACAT1 plays an oncogenic role in most types of cancer. |
• | BLACAT1 manipulate multiple downstream targets via sponging to various miRNAs. |
• | BLACAT1 recruits PRC2, thus inhibiting gene expression at the epigenetic level. |
• | BLACAT1 is a candidate for molecular diagnosis and treatment in cancers. |
Abstract |
Emerging evidence has shown that aberrantly expressed long noncoding RNAs (lncRNAs) play a vital role in various biological processes of tumorigenesis. Bladder cancer associated transcript 1 (BLACAT1) is a novel lncRNA located on chromosome 1q32.1, which regulated multiple downstream targets via serving as a “sponge” for their corresponding microRNAs or by directly interacting with various regulating proteins. In this review, we summarized the role of BLACAT1 in the development and progression of different cancers. We also highlighted that BLACAT1 could be utilized as a potential biomarker and therapeutic target for human cancers.
Le texte complet de cet article est disponible en PDF.Abbreviations : lncRNAs, miRNA, siRNAs, EMT, TCGA, STAD, COAD, READ, PAAD, CESC, OV, UCEC, UCS, qRT-PCR, HCC, LUAD, BRCA, PRAD, ESCA, THCA, BLCA, NPC, ROC, AUC, LNM, OS, DFS, MFS, RIP, ChIP, KIRC, LGG, CSCC, NSCLC, SCLC, ESCC, CRC, HNCs, OSCC, HNSCC, PTC, EZH2, SUZ12, PRC2, CCND2, SERPINB2, BMP2, HOXA5, CCR2, TAM, DNMT1, HDAC1, MDM2, MAPK, STAT3, ATG7, MRP1, LRP1, ABCB1, IC50, VASP, AML
Keywords : Long non-coding RNA, BLACAT1, Biomarker, Cancer
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Vol 132
Article 110808- décembre 2020 Retour au numéro
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