Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review - 19/12/20
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Graphical abstract |
Highlights |
• | Traditional Chinese Medicine (TCM) is important source for modern drug development. |
• | The important role of autophagy in neurodegenerative disease have been summarized. |
• | The TCM compound that regulate autophagy process and exert neuroprotection effects in NDs are highlighted. |
• | TCM compound regulate autophagy are promising for the treatment of NDs. |
Abstract |
Neurodegenerative diseases (NDs) are common chronic diseases related to progressive damage of the nervous system. Globally, the number of people with an ND is dramatically increasing consistent with the fast aging of society and one of the common features of NDs is the abnormal aggregation of diverse proteins. Autophagy is the main process by which misfolded proteins and damaged organelles are removed from cells. It has been found that the impairment of autophagy is associated with many NDs, suggesting that autophagy has a vital role in the neurodegeneration process. Recently, more and more studies have reported that autophagy inducers display a protective role in different ND experimental models, suggesting that enhancement of autophagy could be a potential therapy for NDs. In this review, the evidence for beneficial effects of traditional Chinese medicine (TCM) regulate autophagy in the models of Alzheimer's disease (AD), Parkinson’s disease (PD), and other NDs are presented and common autophagy-related mechanisms are identified. The results demonstrate that TCM which regulate autophagy are potential therapeutic candidates for ND treatment.
Le texte complet de cet article est disponible en PDF.Abbreviations : 6-OHDA, AMPK, α-syn, AD, Aβ, ALS, ATGs, ATP, Bcl2, BCL-XL, CA, CMA, CLEAR, CLC-R17, DPA, ER, GDP, GTP, HSC70, HH, Htt, HD, LAMP2A, MTORC1, mHTT, MPTP, NDs, NFTs, PD, PIP3, PIP, PLG, PP2A, Rheb, Res, SCA3, SNpc, TCM, TFEB, TSC2, ULK1/2, UVRAG/AMBRA
Keywords : Traditional Chinese medicine, Autophagy, Neurodegenerative disease, Neuroprotection
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Vol 133
Article 110968- janvier 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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