Reactive oxygen species in immune cells: A new antitumor target - 19/12/20
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Abstract |
Immune cells have the potential to control the growth of tumor. However, this effect could be offset by immunosuppression associated with an increased production of reactive oxygen species. Multiple studies indicate that the antitumor effect of immune cells is correlated with their antioxidant capacity. This review discusses the role of reactive oxygen species in the tumor microenvironment by describing their distinct effects on different immune cells, including myeloid-derived suppressor cells, regulatory T cells, tumor-associated macrophages, cytotoxic T lymphocytes, natural killer cells, and dendritic cells. In the end, we conclude with the prospect of treatment for cancer by targeting antioxidant defense in immune cells.
Le texte complet de cet article est disponible en PDF.Abbreviations : ROS, MDSCs, Tregs, TAMs, CTLs, NKs, DCs, NADPH, NO, NAC, DMNQ, NK-κB, PD-1, NQO1, PBMCs, ATRA
Keywords : Reactive oxygen species, Immune cells, Immunosuppression, Antioxidant, Tumor micro-environment
Plan
Vol 133
Article 110978- janvier 2021 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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