Early use of NSAIDs including ibuprofen blocks the diffuse inflammation produced by SARS CoV-2 thus might prevent COVID-19 complications, whereas early use of glucocorticoids might encourage the development of COVID-19 complications.
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The pathogenesis of COVID-19 is still waiting to be fully explored and elucidated.
In order to find a valid treatment of COVID-19, we must know better about its exact pathogenesis.
This manuscript provides a novel “lymphocyte distraction theory” to explain COVID-19 pathogenesis and complications.
NSAIDs are suggested to reverse pathogenesis, prevent complications and improve clinical outcomes of COVID-19.
The pathogenesis of Coronavirus disease 2019 is still obscure and the need for exploration of possible mechanisms to suggest drugs based on knowledge should never be delayed. In this manuscript, we present a novel theory to explain the pathogenesis of COVID-19; lymphocyte distraction theory upon which the author has used, in a preprinted protocol, non-steroidal anti-inflammatory drugs (NSAIDs); diclofenac potassium, ibuprofen and ketoprofen, successfully to treat COVID-19 patients. Furthermore, we agree with a recommendation that glucocorticoids should not be used routinely for COVID-19 patients and suggested to be beneficial only for patients with late acute respiratory distress syndrome. A clinical proof of ibuprofen safety in COVID-19 has been published by other researchers and we suggest that early administration of NSAIDs, including ibuprofen, in COVID-19 is not only safe but it might also prevent COVID-19 complications and this manuscript explains some of the suggested associated protective mechanisms.Le texte complet de cet article est disponible en PDF.
Keywords : COVID-19, SARS CoV-2, Lymphopenia, Ibuprofen, Glucocorticoids