Akkermansia muciniphila: A potential novel mechanism of nuciferine to improve hyperlipidemia - 19/12/20
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Graphical abstract |
Nuciferine improved the blood and hepetic lipid levels, while such effect was suppressed after antibiotic administration, indicating that the intestinal microbiota played an essential role in the antihyperlipidemic effect of nuciferine. Metagenomic sequencing analysis found that Akkermansia municiphila was dramatically promoted compared with model group, but it couldn't be detected after antibiotic administration, hence it had a potential to be the target.
Highlights |
• | Gut microbiota is a potential target for hyperlipidemia therapy. |
• | A combination of pseudosterile mouse and metagenome technology enables microbiota target research. |
• | Akkermansia municiphila may directly related to its effect as a most abundant probiotic under nuciferine administration |
• | The researvh provide reference in edible ingredients’ research of hyperlipidemia with poor bio-availability |
Abstract |
Background |
Intestinal microbiota is a novel drug target of metabolic diseases, especially for those with poor oral bioavailability. Nuciferine, with poor bioavailability, has an anti-hyperlipidemic effect at low dosages.
Purpose |
In the present study, we aimed to explore the role of intestinal microbiota in the anti-hyperlipidemic function of nuciferine and identify the key bacterial targets that might confer the therapeutic actions.
Methods |
The contribution of gut microbes in the anti-hyperlipidemic effect of nuciferine was evaluated by conventional and antibiotic-established pseudo-sterile mice. Whole-metagenome shotgun sequencing was used to characterize the changes in microbial communities by various agents.
Results |
Nuciferine exhibited potent anti-hyperlipidemic and liver steatosis-alleviating effects at the doses of 7.5-30 mg/kg. The beneficial effects of nuciferine were substantially abolished when combined with antibiotics. Metagenomic analysis showed that nuciferine significantly shifted the microbial structure, and the enrichment of Akkermansia muciniphila was closely related to the therapeutic effect of nuciferine.
Conclusions |
Our results revealed that gut microbiota played an essential role in the anti-hyperlipidemic effect of nuciferine, and enrichment of Akkermansia muciniphila represented a key mechanism through which nuciferine exerted its therapeutic effects.
Le texte complet de cet article est disponible en PDF.Abbreviations : Abs, AUC, CMC-Na, HFD, LDL-c, NEFA, NF, OGTT, OTU, PCoA, PCR, PGC1α, PPARα, stat, TC, TG
Keywords : Akkermanisa municiphila, Nuciferine, Intestinal microbiota, Hyperlipidemia, Lotus, Phytotherapy
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Vol 133
Article 111014- janvier 2021 Retour au numéro
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