Pre-clinical investigation of STAT3 pathway in bladder cancer: Paving the way for clinical translation - 19/12/20
, Milad Ashrafizadeh j, k, ⁎ , Haroon Khan l, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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| pages | 12 |
| Iconographies | 5 |
| Vidéos | 0 |
| Autres | 0 |
Graphical abstract |
Highlights |
• | Bladder cancer still remains one of the leading causes of death worldwide. |
• | STAT3 is under attention in cancer therapy due to its capability in promoting cancer proliferation and metastasis. |
• | STAT3 hyperactivation ensures metastasis and growth of bladder cancer cells |
• | Anti-tumor compounds down-regulate STAT3 expression in bladder cancer suppression. |
• | Long non-coding RNAs, microRNAs, circular RNAs, and EZH2 regulate STAT3 expression in bladder cancer. |
Abstract |
Effective cancer therapy requires identification of signaling networks and investigating their potential role in proliferation and invasion of cancer cells. Among molecular pathways, signal transducer and activator of transcription 3 (STAT3) has been of importance due to its involvement in promoting proliferation, and invasion of cancer cells, and mediating chemoresistance. In the present review, our aim is to reveal role of STAT3 pathway in bladder cancer (BC), as one of the leading causes of death worldwide. In respect to its tumor-promoting role, STAT3 is able to enhance the growth of BC cells via inhibiting apoptosis and cell cycle arrest. STAT3 also contributes to metastasis of BC cells via upregulating of MMP-2 and MMP-9 as well as genes in the EMT pathway. BC cells obtain chemoresistance via STAT3 overexpression and its inhibition paves the way for increasing efficacy of chemotherapy. Different molecular pathways such as KMT1A, EZH2, DAB2IP and non-coding RNAs including microRNAs and long non-coding RNAs can function as upstream mediators of STAT3 that are discussed in this review article.
Le texte complet de cet article est disponible en PDF.Abbreviations : STAT3, IL-6, APRF, SH2, ER, miR, BC, EGF, IFN, SOCS, PIAS, PTPass, APR, BK, MMP-2, KP, TCC, SCC, COX-2, PGE2, Pae, RPA, TME, Gln, TCA, EZH2, Msi2, PLC, LDH, RORC, EGFR, EMT, IDO1, lncRNAs, circRNAs, RACGAP1, ES1, ESR1, DANCR, CCR7
Keywords : Signal transducer and activator of transcription 3 (STAT3), Bladder cancer, MicroRNA, LncRNA, Metastasis, Chemoresistance
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Vol 133
Article 111077- janvier 2021 Retour au numéro
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