Immediate release melatonin is indicated for circadian rhythm disorders.
The maximum chronobiotic effect is time dependent (4 to 6hours before sleep onset) and dose dependent (low dosages).
Higher dosages half an hour before bedtime has a small chronobiotic effect and a soporific effect.
For non-24-hour sleep/wake disorder, melatonin should be administered when the patient's circadian rhythm coincides with conventional sleep/wake schedules.
Melatonin should be associated with sleep hygiene and cognitive behavior therapy.
The French society of medical research on sleep (SFRMS) appointed a group of experts to conduct a consensus conference in order to study the indications and prescription status of exogenous melatonin (MEL). Eleven sleep physicians/researchers investigated in subgroups the use of MEL in different domains of healthcare in line with their subspecialties (circadian sleep/wake rhythm disorders, psychiatric disorders, neurological disorders, pediatric and neurodevelopmental disorders). In this article we present a summary of the main conclusions of the expert group on MEL therapy in circadian sleep/wake rhythm disorders such us delayed sleep-wake disorder, non-24-hour sleep wake rhythm disorder and jet lag.Le texte complet de cet article est disponible en PDF.
Keywords : French consensus, Melatonin, Delayed sleep phase, Non-24-hour, Jet lag