Psoriasis is not associated with cognition, brain imaging markers, and risk for dementia: The Rotterdam Study - 11/02/21
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Abstract |
Background |
Based on increased cardiometabolic comorbidities, inflammation, and an overlap in genetics with Alzheimer disease, psoriasis patients might be at risk for cognitive dysfunction and dementia.
Objective |
To compare cognition, magnetic resonance imaging (MRI)–markers, and dementia risk in psoriasis and nonpsoriasis participants in the population-based Rotterdam Study.
Methods |
We identified 318 psoriasis and 9678 nonpsoriasis participants (mean age 66.1 years, 58% women). The association of psoriasis with cognitive function, mild cognitive impairment, and MRI-markers of brain damage was examined by linear and logistic regression. Dementia risk was calculated using Cox regression. Models were adjusted for age, sex, education, and cardiovascular risk factors.
Results |
Cognitive test scores and volumetric, microstructural, focal measures on brain MRI did not differ between psoriasis (28% systemic and ultraviolet treatment) and nonpsoriasis participants, and psoriasis was not associated with mild cognitive impairment (adjusted odd ratio 0.87, 95% confidence interval 0.53-1.43). During 115.000 person-years of follow-up, 810 incident dementia cases (15 among psoriasis patients) occurred. After adjusting for confounders, psoriasis was associated with a lower risk of developing dementia (adjusted hazard ratio 0.50, 95% confidence interval 0.28-0.91).
Limitations |
Limited dementia cases among psoriasis patients.
Conclusion |
In this population-based study, psoriasis was not associated with preclinical markers or higher dementia risk.
Le texte complet de cet article est disponible en PDF.Key words : brain MRI-correlates, dementia, global cognition factor, neuropsychological tests, psoriasis
Abbreviations used : AD, CI, HR, LDST, MCI, MRI, MMSE, WML
Plan
Funding sources: Supported by the Erasmus University Medical Center and Erasmus University, Rotterdam; the Netherlands Organisation for Scientific Research; the Netherlands Organization for Health Research and Development; Research Institute for Diseases in the Elderly; Ministry of Education, Culture, and Science; Ministry of Health, Welfare, and Sports; European Commission (DGXII); and Municipality of Rotterdam. |
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Conflicts of interest: None disclosed. |
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Reprints not available from the authors. |
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